Based On The Dictionary Of Traditional Chinese Medicine Prescriptions,to Explore The Compatibility Characteristics Of All Previous Dynasties Diabetes Mellitus

Objective: By collecting the prescriptions about Diabetes,and The upper,middle and lower levels of diabetes in the Dictionary of traditional Chinese medicine prescriptions,Sorted out the past dynasties for the treatment of diabetes prescription drugs,using statistical methods,to explore the law of traditional Chinese medicine treatment of diabetes,to analyze the characteristics of drug compatibility used in the treatment of diabetes.To provide more clinical ideas for the treatment of diabetes with traditional Chinese medicine,in order to improve the clinical application of traditional Chinese medicine in the treatment of diabetes.Methods: Through the collection and input of relevant items in the dictionary of traditional Chinese medicine prescriptions.Excel database was established from the aspects of prescription name,prescription source,drug composition,drug properties,drug meridian attribution,efficacy,indications and so on,by analyzing the frequency of drug use in each period of the past dynasties,high-frequency drugs are obtained,then the high-frequency drugs in each period were clustered and analyzed,the association between drugs can be obtained by cluster analysis,the prescription was obtained according to the method,and the method was established according to the syndrome type,the treatment principles and the main etiology and pathogenesis were deduced,and the compatibility rules of diabetes drug formulations were summarized.Results: Medication for diabetes has gone through three stages:In the tang dynasty and before the tang dynasty,the most frequently used drugs for curing diabetes were tonic drugs and heat-clearing drugs,tonic drugs accounted for 27.46 percent and heat-clearing drugs 24.49 percent;damp-clearing drug、astringent、drugs for relieving Exterior Disorder、drying dampness and resolving phlegm、interior-warming drug,the cumulative frequency of the five drugs was 28.57%.In filling empty medicaments,filling qi medicaments occupies the first place,Yin tonic drugs occupy the second place.It can be seen that the main pathogenesis of diabetes was thought by doctors in this period "deficiency of vital energy" 、 "deficiency of yin" 、 "domination of heat".Through cluster analysis,it is concluded that the main compatibility of drugs in this period is Qi tonic drugs compatible with clearing damp drugs,heat-clearing drugs with Yin drugs,drugs for relieving Exterior Disorder compatible with heat-clearing drugs.During the song,jin and yuan dynasties,the cumulative frequency of the use of tonic drugs and heat-clearing drugs reached 52.36%.It shows that the etiology of diabetes in this period is dominated by the weakness of the viscera and the excessive heat.Through cluster analysis,it is concluded that the main compatibility of drugs in this period is Qi tonic drugs compatible with clearing damp drugs;Antipyretic drugs compatible with Yin drugs;Nourishing Yin medicine compatible with tonic Yang medicine;Antipyretic dryness and dampness are compatible with each other.In the treatment of diabetes in the Ming and qing dynasties,the highest frequency was 31.27% for tonic drugs and 26.86% for heat-clearing drugs,the cumulative frequency was 58.13%.Through cluster analysis,get this period of medicine compatibility,in addition to heat-clearing drugs compatible with Nourishing Yin medicine and antipyretic dryness and dampness are compatible with each other;and Qi tonic is compatible with astringent and clearing damp;Blood tonic medicines compatible with astringent;Yin drugs compatible with Blood tonic medicines;clearing heat-fire drugs compatible with clear heat and dry dampness drugs.The dictionary of traditional Chinese medicine prescriptions for the treatment of diabetes contains 626 prescriptions cluster analysis showed that 7 groups of commonly used compatible drugs were obtained:(1)Gua lou、Wang gua gen、Huang lian、Ku shen、Huang qin;(2)Shan zhu yu、Wu mei、Bai shao;(3)Gan cao、Ren shen、Fu ling、Chi fu ling、Ji nei jin、Huang qi;(4)Mai men dong、Tian hua fen、Ge gen、Shi gao;(5)Dang gui、Rou gui;(6)Di gu pi、Zhi mu、Ze xie;(7)Shu di huang、Tu si zi、Sang piao xiao、Rou cong rong.Conclusion: In tang dynasty and before tang dynasty,doctors paid attention to the application of tonics,heat-clearing drugs,clearing damp drugs and antipyretic drugs in the treatment of diabetes,it can be seen that the etiology and pathogenesis of diabetes in that period were mainly heat evil impairment of fluid、six-excess external contraction、insufficiency of the spleen with overabundance of dampness、treatment pay attention to clearing heat and reinforcing body fluid、relieving exterior syndrome by dispersion.Doctors in song,jin and yuan dynasties also attached importance to the application of qi tonic and heat-clearing medicine.On this basis,it was compatible with clearing damp and Yang tonic,it can be seen that the doctors in this period also realized that yin-yang deficiency、retention of damp-heat in the interior is also an important pathogenesis of diabetes mellitus.During this period,the main treatment of diabetes has:replenishing qi to invigorate the spleen、clearing heat and moistening dryness、heat-clearing and damp-drying、nourishing yin and clearing heat、tonifying yin and yang.Doctors in the Ming and qing dynasties inherited their predecessors’ treatment of diabetes on the basis of prescription drugs,attach importance to the compatibility of astringent drugs,it is recognized that the deficiency of spleen and the leakage of Yin fluid are also factors leading to diabetes mellitus.During this period,the main treatment of diabetes has:invigorating spleen and supplementing qi、retaining yin with astringent、clearing heat and moistening dryness、clear heat and dry dampness、Ziyin yangxue.From the han dynasty to the qing dynasty,there are 626 prescriptions for the treatment of diabetes,according to the results of medication frequency and cluster analysis,get Mutual compatibility of the main medicines used in the past to treat diabetes has:tonic compatibility with tonic,tonic compatibility with heat-clearing drug,tonic compatibility with inducing astringency drugs,tonic compatibility with damp-clearing drug,heat-clearing drug compatibility with heat-clearing drugs,heat-clearing drug compatibility with damp-clearing drug.