The Correlation Between Plasma Homocysteine And Bone Metabolic Markers In Patients With Type 2 Diabetes Mellitus

Objective: Through the screening of patients with type 2 diabetes on plasma homocysteine levels of ammonia,observe the plasma homocysteine level,the analysis of the influence factors of homocysteine,to investigate the influence of bone metabolism in patients with type 2 diabetes mellitus homocysteine and related mechanism;provide a simple and effective observation index for the prediction of the occurrence and development of diabetes osteoporosis,for the prevention of diabetic osteoporosis for new methods and ideas.Methods: Signed patients,inpatients and outpatients with type 2 diabetes mellitus were enrolled.Hcy levels were determined in all patients.Patients were then divided into normal Hcy group with Hcy <20umol/L and high Hcy group with Hcy> 20 umol / L respectively,each group containing 120 patients.?-crosslaps(?-CTX)and N-terminal propeptide of type I collagen(P1NP)were detected in both groups.The analysis of correlation between plasma homocysteine and ?-CTX and P1 NP were conducted to see whether there were statistical differences.Results: 1.There was no significant difference in age,body mass index,glycosylated hemoglobin,fasting blood glucose,serum calcium,serum phosphorus,alkaline phosphatase,triglyceride,low density lipoprotein between normal Hcy group and high Hcy group(P> 0.05).However,there was significant difference in blood pressure between the two groups(P <0.05).2.There was no significant difference in body mass index,glycosylated hemoglobin,fasting blood glucose,serum calcium,serum phosphorus,alkaline phosphatase,triglyceride,low density lipoprotein between males group and females group(P> 0.05).3.P1 NP level was significantly lower in high Hcy group(P <0.05)and ?-CTX level was significantly higher in the high Hcy group than that in the normal Hcy group(P <0.05).4.Hcy level in the type 2 diabetes mellitus was correlated with P1NP(P <0.05),positively correlated with?-CTX(P <0.05).Conclusion: There exists a correlation between Hcy,?-CTX and P1 NP in patients with type 2 diabetes mellitus.Conventional Hcy detection can be an early screening of patients with high risk of osteoporosis,which contributes to an early intervention of osteoporosis treatment of patients with type 2 diabetes.