| Objective: To observe Chaihu-Jia-Longgu-Muli-Decoction of diseases with ease type MHD patients with depression with serum BDNF levels before and after,HAMD and KDQOL-SFTM1.3 score of traditional Chinese medicine(TCM),is just the change of the integral,understanding the MHD Chaihu-Jia-Longgu-Muli-Decoction with depressive symptoms and quality of life of patients with depression,explore its possible mechanism,and improve the quality of life of patients.Methods:According to the inclusion and exclusion criteria of this study,86 patients with maintenance hemodialysis were selected enrolled from the hemodialysis centre of The People’s Hospital of Fujian Province,and useing random trial method divided into control group and trial group,with 43 cases each.In maintenance hemodialysis,on the basis of the control group with escitalopram citalopram treatment,treatment group with Chaihu-Jia-Longgu-Muli-Decoction treatment,two groups of a course of 8 weeks.The changes of serum BDNF were detected before and after treatment,and the evaluation scores of HAMD,kdqol-sftm1.3 and the changes of TCM syndrome score were eveluated,and statistical analysis was performed.Results: 1.General information before treatment,serum BDNF level,HAMD and kdqol-sftm1.3 scores,TCM syndrome score and safety index showed no significant difference between the trial group and the control group(P > 0.05),which was comparable.2.After treatment,serum BDNF level and HAMD score of the two groups were both higher than before,with no statistically significant difference between the two groups.3.In terms of sf-36 after treatment,scores of all dimensions in the experimental group increased(P < 0.05),while scores of other dimensions in the control group increased(P < 0.05)except physical pain,general health and mental health.In KDTA ways,two groups in addition to the effect of kidney disease,social support and medical staff to encourage outside,the rest of the dimension scores are compared with the previous increase(P < 0.05),the comparison between groups: 8 weeks after treatment,the trial group on social networking,sleep quality,patient satisfaction,physiological function,physiological functions,body pain,general health,energy,social function and mental health,a total of 10 dimension score compared with control group,the differences were statistically significant(P < 0.05).4.After treatment,TCM syndrome scores of patients in both groups were lower than before(P < 0.05),and the difference between groups was not statistically significant(P > 0.05).Conclusions:1.The results of this study show that both Chaihu-Jia-Longgu-MuliDecoction and western medicine can improve the serum BFNF level of MHD patients with depression,improve their depressive symptoms,and improve their quality of life scores to varying degrees,with similar clinical efficacy.2.Compared with western medicine,Chaihu-Jia-Longgu-Muli-Decoction can better improve the quality of life of patients in 10 aspects,including social quality,sleep,patient satisfaction,physiological function,physiological function,physical pain,general health,energy,social function and mental health 3.In the process of this study,no obvious side effects of bupleurum chinense and Chaihu-Jia-Long gu-Muli-Decoction were found,which was safe and reliable and had good clinical and practical value. |
PDF Full Text Request