Relationship Between HP Infection And Expression Of EGFR In Gastric Cardia Cancer

Cardiac cancer is one of the common malignant tumors of the digestive tract.Helicobacter pylori(Hp)infection has been shown to be associated with a variety of digestive tract diseases.The current correlation between HP infection and cardiac cancer is still controversial.This study marks EGFR by immunohistochemistry.This method detects the expression of EGFR protein in the specimen tissues to explore the pathogenesis of cardiac cancer with HP infected.Purpose: To study the correlation between Helicobacter pylori(HP)infection and EGRF protein expression in cardiac cancer.Methods: We collected 49 patients who was in the Nanjing First Hospital from January 2012 to December 2017.They were diagnosed with cardia cancer and underwent surgery.In addition,we also collected 56 patients who was in the Nanjing First Hospital from January 2016 to June 18,2016 as non-cardia cancer group.They were diagnosed with gastric cancer and underwent surgery.(The diagnosis was confirmed bypostoperative pathological diagnosis)We used the C14 breath test to detect Helicobacter pylori infection in both groups.We used immunohistochemistry to label EGFR and detect its protein expression in the experimental and control groups.We compared the relationship between EGFR protein expression and clinicopathological features in cardiac cancer tissues.We compared the relationship between EGFR protein expression and HP infection in gastric cancer tissues.We wanted to find out whether there is a difference in EGFR protein expression between HP-positive cardiac cancer and non-cardia cancer.Results: 1.The relationship between HP infection and cardiac cancer: There is no significant correlation between HP infection and cardiac cancer.There is no significant correlation between HP infection and gender,age and stage of cardiac cancer patients(P>0.05).2.The relationship between the positive expression of EGFR and the pathological features of cardiac cancer: the positive expression of EGFR was not associated with the gender and age of patients with cardiac cancer(P>0.05),and was associated with the stage and lymphatic metastasis of patients with cardiac cancer(P <0.05);3.The relationship between EGFR protein expression of HP infection in gastric cardia cancer: The expression rate of EGFR protein positive forHP infection of gastric cardia cancer is significantly higher than that of HP infection negative EGFR protein,indicating that HP infection promotes positive expression of EGFR in gastric cardia cancer;non-cardia cancer The relationship between HP infection-positive EGFR protein expression: the expression rate of EGFR protein positive for non-cardiac cancer HP infection was significantly higher than that of HP infection-negative EGFR protein,indicating that HP infection promotes the positive expression of EGFR in non-cardia cancer;4.The expression of EGFR in the gastric cancer group and the non-cardia cancer group: the positive expression rate of EGFR protein in the gastric cardia cancer group was 59.2%,and the positive expression rate of EGFR protein in the non-cardia cancer group was 39.3%.The positive expression rate of EGFR protein in the two groups.In comparison,the difference was statistically significant.Conclusions: 1.HP infection is associated with overexpression of EGFR in Cardiac cancer.The high expression of EGFR in HP-induced cardiac cancer tissue results of multiple mechanisms.2.The positive expression rate of EGFR in gastric cardia cancer group is higher than that in non-cardia cancer group,which indicates that cardia cancer is more aggressive than gastric cancer.