Experimental Study On The Protective Effect Of Atorvastatin On Cisplatin Cardiotoxicity

Objective: Cisplatin(CDDP)is considered to be an effective anti-tumor drug;however,cardiotoxicity affects its clinical application.Atorvastatin is a commonly used drug for cardiovascular diseases and has been proven to have multiple functions such as lipid lowering,anti-inflammatory and anti-oxidation.This study aimed to investigate the protective effect of atorvastatin calcium on cisplatin-induced cardiotoxicity in rats.Methods: Wistar rats were randomly divided into control group,cisplatin cardiotoxicity model group and atorvastatin + cisplatin intervention group.The model group was treated with cisplatin 5 mg/kg intraperitoneally every other day to prepare a cardiotoxicity model induced by cisplatin.Atorvastatin + cisplatin intervention group atorvastatin was administered by intragastric administration of 15 mg/kg/day 1 hour before cisplatin,and the control group was given an equal amount of 0.9% sodium chloride.Each group was intervened for one week.After one week,the heart function of the rats was detected by B-ultrasound.The myocardial enzymes such as lactate dehydrogenase(LDH)were detected by biochemical detection of myocardial injury markers in rat blood and heart tissue samples.The degree of myocardial damage was detected by histopathology.Results: 1 There were significant differences in P<0.05 between aspartate aminotransferase(AST),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),creatine kinase(CK)model group,treatment group and control group.Statistical significance.2 Significant differences in ejection fraction(FE),left ventricular end-systolic diameter(LVIDs),left ventricular end-diastolic diameter(LVIDd)model group,treatment group,and control group P<0.05.3 Histopathological examination showed that the model group and the treatment group had different degrees of damage compared with the control group,the cells were atrophied,the muscle fibers were loosely arranged,the fracture,the myocardial transverse stripes disappeared,and the nuclear fragmentation occurred.Conclusion: This experiment shows that cisplatin can induce cardiotoxicity,atorvastatin can inhibit cisplatin-induced cardiotoxicity and protect myocardial damage,and atorvastatin has protective effect on cisplatin-induced heart damage.