| Objective:The incidence of white matter hyperintensities?WMH?has risen in recent years,but the pathogenesis of WMH is still not clear.Therefore,it is important to explore the correlations between the blood-brain barrier permeability and the severity of WMH by DCE-MRI.Methods:Fifty-five patients with WMH were enrolled and divided into 3 grades based on Fazekas score,17 patients in grade 1,20 patients in grade 2,and 18 patients in grade 3 from September 2017 to May 2018.They received brain routine MR and DCE-MRI scan,and all images were analyzed by the Omni-Kinetics analysis software.The differences of Ktrans value about WMH and normal appearing white matter?NAWM?among the three groups were analyzed by one-way analysis of variance,the correlations between the severity of WMH and the blood-brain barrier permeability were analyzed by Spearman correlation.Results:The differences of Ktrans value about WMH and NAWM among the three grades of WMH were both statistically significant?P<0.05?,the value of Ktrans of WMH region was?0.120±0.028?10-2/min,?0.167±0.029?10-2/min and?0.191±0.028?10-2/min respectively.The correlations between the severity of WMH and the blood-brain barrier permeability were positive?r=0.725,P<0.05?.Conclusion:Our findings emphasized the importance of BBB permeability disruptions in the pathogenesis of WMH and provided new ideas and directions for the prevention and treatment of WMH. |
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