Application Of Rapid Thromboelastography In Perioperative Period Of Patients With Gynecologic Cancer

Objective:To investigate the dynamic changes of perioperative coagulation function in gynecologic oncology patients and its clinical significance by rapid thromboelastogram(r-TEG)Methods:From January 2016 to January 2017,160 patients with cervical malignant tumor in Cangzhou Hospital of Integrated Traditional Chinese and western of Hebei province were selected as the experimental group,and the subgroups were divided according to the different stages of the tumor,the depth of infiltration and the metastasis of lymph nodes.All the patients were examined before and after the operation,four items of coagulation function and D-Dimer and r-TEG were taken,and 60 healthy subjects were selected as normal control group.The patients in normal control group were examined by four items of coagulation function,DDimer and r-TEG,and the dynamic changes of coagulation function during the perioperative period of the control group were analyzed.Results:Compared with patients in the control group,the r-TEG parameters R and K were significantly decreased and the angles,MA and CI were significantly increased in the experimental group(P<0.05).There was no significant difference between the two groups in the observation values of R,LY30 and other stages of the tumor(P>0.05).Compared with patients with or without lymph node metastasis,the r-TEG monitoring values were significantly different(P <0.05).Conclusion:Patients with gynecologic malignancies have hypercoagulable state during perioperative period,and have positive correlation with tumor stage,depth of tumor invasion and lymph node metastasis.Dynamic monitoring of patients with gynecological malignant tumors perioperative rTEG can provide valuable clinical coagulation function information,and to improve the safety of gynecological malignancies surgery and promote postoperative recovery of patients with positive clinical significance.