Pancreatic Fat Content Is Associated With Beta-cell Function And Insulin Resistance In Chinese Type 2 Diabetes Subjects

Background and Objective:The pathogenesis of type 2 diabetes mellitus(T2DM)is characterized by insulin resistance and b-cell dysfunction.Earlier studies reported that increased levels of pancreatic fat may lead to the development of b-cell dysfunction and insulin resistance;however,this is controversial.The present study aimed to demonstrate the relationship between pancreatic fat content(PFC)and insulin secretion-resistance in Chinese T2DM patients.Methods:1.Seventy-eight Chinese subjects with T2DM were recruited from the Endocrinology Department of Zhongda Hospital from 2015 to 2017.Thirty-five volunteers who had not been diagnosed with diabetes and prediabetes were recruited by advertising.2.Arrange the patients’ name,age,gender,course of diabetes,height,weight,waist circumference,hip circumference,and blood pressure.3.PFC and liver fat content(LFC)were quantified by 3-point Dixon method of the abdominal axial routine scan and T2* correction.4.Biochemical indexes were measured which including total cholesterol,triglyceride,high-density lipoprotein,and low-density lipoprotein.5.75-g oral glucose tolerance test and oral glucose insulin releasing test were performed.Whole blood samples were drawn at 0,30,60,120,180 min to serum C-peptide levels and 0,120 min to blood glucose.6.Using SPSS 16.0 software,the difference of general data between the two groups was analyzed by Student’s t test;PFC was stratified into four groups by quartiles and the comparisons between groups were performed with one-way analysis of variance or Nonparametric test;the risk factors of PFC were analyzed by multiple linear regression analysis;correlation between PFC and islet beta cell function and insulin resistance was analyzed by Pearson and Partial correlation analysis,P<0.05 statistically significant.Result:1.The median PFC was significantly higher in patients with T2DM compared with the non-diabetic subjects(7.06% vs 5.36%,P<0.01).2.PFC was correlated with body mass index(BMI),liver fat content(LFC)and age in two groups.3.PFC was positively associated with insulin secretion,insulin resistance,earlyand late-phase in male T2DM subjects(r>0.00,p<0.05),after adjusting for BMI,LFC and age,the association still existed,however,it was absent in non-diabetic and female T2DM subjects(p>0.05).4.The relationships were more obvious in male T2DM subjects with a course of disease less than 4 years.Conclusion:1.Pancreas is also an important organ of visceral fat deposition.2.PFC can affects the secretion of insulin and aggravates insulin resistance.3.Pancreatic fat might represent a potential risk factor for the development of T2DM.It should be found early and intervened in time.