Analysis Of Clinical Characteristics Of Chemotherapy Maintenance Therapy For Advanced Non-small Cell Lung Cancer

Objective: To explore the influencing factors of maintaining chemotherapy benefit in patients with advanced non-small cell lung cancer.Method: Collect 50 patients with advanced non-small cell lung cancer who were maintained for treatment after first-line chemotherapy in Qinghai University affiliated hospital from October 2015 to October 2018,according to PFS divided into a(pfs?6 months),B(pfs<6 months)two groups,retrospective analysis of the general situation of patients(gender,age,smoking history,BMI,Functional status score),tumor related factors(tumor size,lymph node metastasis,distant metastasis,location,pathological type,degree of differentiation),the effect of therapeutic factors on its survival.The single factor and multi-factor are analyzed respectively by Kaplan-meier survival analysis and Cox regression model of SPSS19.0 software.?~2 tests are used for inter-group comparisons.Results: 1.Single factor analysis showed that: the general situation of patients: gender,age,smoking history and maintenance of treatment of PFS has nothing to do.Normal range and median PFS in overweight patients were superior to those with low BMI(?~2=6.079,p=0.048),statistically significant(p<0.05),and BMI was associated with maintaining the treatment of PFS.Tumor related factors: the stages of the tumor were independent of the PFS that maintained the treatment.The median PFS in patients with central lung cancer was much lower than that of the surrounding type(?~2=11.090,p=0.001),the middle of the tumor in high school differentiation was better than that of the patients with low differentiation(?~2=10.431,p=0.001),and the patients with Adenocarcinoma had an advantage over the median PFS in patients with squamous cell carcinoma(?~2=6.241,p= 0.012);statistically significant(p<0.05).Therapeutic factors: Maintenance of chemotherapy ? 5 cycle and maintenance chemotherapy < 5 weeks of 11.5 months and 4 months(?~2=24.986,p=0.001),respectively,statistically significant(p<0.05).2.The inclusion of a single factor in the meaningful analysis of multiple factors shows: the location of the disease(?~2=5.144,p=0.023),the degree of differentiation(?~2=12.810,p=0.001),BMI(?~2=5.742,p=0.017),the maintenance of the treatment cycle(?~2= 8.243,p<0.05)is an independent factor affecting PFS.3.50 patients with advanced non-small cell lung cancer,group A compared with Group B in the degree of differentiation(?~2=5.502,p=0.019),BMI(?~2=7.516,p=0.023),distant metastasis(?~2=5.059,p=0.025),maintenance of the number of chemotherapy cycles(?~2=15.467,p= 0.001)The difference between the two groups was statistically significant(p<0.05).Conclusion: 1.The location,degree of differentiation,BMI and maintenance of chemotherapy cycles in patients with advanced non-small cell lung cancer are independent factors that affect the survival time of maintenance chemotherapy without progress.2.Patients with high school differentiation,BMI in the normal range,no distant metastasis,maintenance chemotherapy for more than 5 weeks can benefit from maintenance treatment.