Correlation Between Metabolic Syndrome And Serum BDNF

Objective The aim of this study is to explore the roles of Brain-derived neurotrophic factor(BDNF)in patients with metabolic syndrome and to investigate the relationship between BDNF and its possible pathogenesis in patients with metabolic syndrome,the correlation between BDNF and MS components.Methods A total of 61 patients with metabolic syndrome admitted to the Department of Endocrinology Metabolism,Second Hospital of Lanzhou University were enrolled.A total of 61 patients,36 males and 25 females,met the current diagnostic criteria for metabolic syndrome in 2013.In the same period,35 physical health examinations were performed at the physical examination center of the Second Hospital of Lanzhou University,including 24 males and 11 females.The general clinical data of all participants were collected and the plasma BDNF concentration was detected by by enzyme-linked immunosorbent assay.Data processing was performed using SPSS 24.0 statistical software.The general clinical data and plasma BDNF concentrations in the metabolic syndrome group and the control group were compared.The independent sample T test was used to analyze the correlation between plasma BDNF and metabolic syndrome and components by Pearson correlation analysis and binary logistic regression analysis.Results 1.BMI,abdominal circumference,fasting blood glucose,Glycated hemoglobin,systolic blood pressure,triglyceride and insulin resistance index in the metabolic syndrome group were higher than those in the healthy control group(F=3.597,11.814,14.905,2.580,0.082,0.610,6.121,P <0.05).High-density lipoprotein in the metabolic syndrome group was lower than that in the healthy control group(F=0.170,P<0.05).2.There was no significant difference in age,diastolic blood pressure,low density lipoprotein,and blood uric acid between the metabolic syndrome group and the control group.3.BDNF in the metabolic syndrome group was lower than that in the healthy control group(F=0.06,P<0.05).4.Pearson correlation analysis showed that plasma BDNF was negatively correlated with abdominal circumference(r=-0.264,P<0.01),and positively correlated with high-density lipoprotein(r=0.327,P<0.01).5.Binary Logistic regression analysis showed that fasting blood glucose(OR =1.568),systolic blood pressure(OR = 1.101),and insulin resistance index(OR =1.589)were risk factors for metabolic syndrome,and BDNF(OR = 0.001)was a protective factor for metabolic syndrome.Conclusions The plasma BDNF concentration in patients with metabolic syndrome was significantly lower than that in healthy controls.Plasma BDNF was associated with components of metabolic syndrome.Plasma BDNF may be involved in the pathogenesis of metabolic syndrome.