| Objective:To establish a comprehensive prediction model of lymph node metastasis after neoadjuvant chemotherapy for breast cancer,evaluate the situation of lymph node metastasis after neoadjuvant chemotherapy,and guide the selection of clinical operation plan.Methods:The clinical and imaging data of 143 patients with neoadjuvant chemotherapy for breast cancer from January 2015 to December 2018 were retrospectively analyzed,and the patients were divided into metastatic group and non-metastatic group according to postoperative lymph node pathology.Univariate analysis was performed by chi-square test and t-test.Indicators with P < 0.05 were included in multivariate Logistic regression analysis.The nomogram of the comprehensive prediction model of lymph node metastasis after neoadjuvant chemotherapy for breast cancer was constructed by multi-factor analysis with statistically significant indexes(P < 0.05),and the ROC curve was applied to evaluate the performance of the model.Results:Univariate analysis showed that chemotherapy regimen,lymph node biopsy before chemotherapy,preoperative physical examination,preoperative color doppler ultrasound,preoperative CT/MRI,and RECIST grading have predictive effects on axillary lymph node metastasis.Multivariate analysis showed that pathology,preoperative color doppler ultrasound and RECIST grading are independent predictors of axillary lymph node metastasis after neoadjuvant chemotherapy.The area under the curve,specificity and sensitivity of the predictive model of lymph node metastasis after neoadjuvant chemotherapy for breast cancer were0.785,85.4% and 59.8% respectively.Conclusion:The comprehensive prediction model of lymph node metastasis after neoadjuvant chemotherapy for breast cancer has a good prediction ability for axillary lymph node metastasis and can provide clinical guidance for the selection of appropriate surgical methods. |
