Correlation Between Expression Of ABCG2 And Ki-67 And Chemosensitivity In Breast Cancer

Objective: By assessing the changes of tumor volume and the number and size of axillary lymph nodes in invasive breast cancer patients before and after neoadjuvant chemotherapy,the expression levels of ABCG2 and Ki-67 in breast cancer puncture specimens before neoadjuvant chemotherapy were detected.The results of the two experiments comprehensively analyzed the accuracy of ABCG2 and Ki-67 combined to determine the sensitivity of chemotherapy.Methods: Selected from the Department of Thyroid Breast Surgery,People's Hospital of China Medical University from November 2015 to November 2018,60 cases of women with invasive breast cancer diagnosed by hollow needle puncture.The pathological specimens confirmed by puncture were fixed with 4% formaldehyde and embedded in paraffin.A number of sections of 4 ?m thick sections were continuously prepared and stained.The expression levels of ABCG2 and Ki-67 in these samples were detected by immunohistochemical sp method.Subsequently,neoadjuvant chemotherapy with TE regimen was confirmed in eligible cases.After 4 cycles of neoadjuvant chemotherapy,combined with neoadjuvant chemotherapy and neoadjuvant chemotherapy,the tumor volume and the number and size of axillary lymph nodes were analyzed to analyze ABCG2 and Correlation between the expression level of Ki-67 and chemosensitivity.Results: 1.The positive expression rates of ABCG2 and Ki-67 in 1.60 breast cancer tissues were 56.7% and 61.7%,respectively.The expression levels of ABCG2 and Ki-67 were positively correlated with the size of breast tumors and the number and size of axillary lymph nodes(P<0.01).2.The expression levels of ABCG2 and Ki-67 were not significantly correlated with the expression levels of ER and PR.Sex(P > 0.05);3.60 patients who received TE regimen with neoadjuvant chemotherapy had a negative correlation with the expression of ABCG2(P < 0.01);4.60 patients who received TE regimen with neoadjuvant chemotherapy The expression level of Ki-67 was positively correlated(P<0.01).The sensitivity of ABCG2 combined with Ki-67 to judge the efficacy of neoadjuvant chemotherapy was higher than that of ABCG2 and Ki-67 alone(P > 0.05).Conclusion: This study found that the positive expression rate of ABCG2 was positively correlated with breast cancer volume and clinical stage;the expression level of ABCG2 was negatively correlated with the efficacy of neoadjuvant chemotherapy for breast cancer.The expression level of Ki-67 was positively correlated with tumor size and lymph node number and size of breast cancer.The expression level of Ki-67 was positively correlated with the efficacy of neoadjuvant chemotherapy.The expression levels of ABCG2 and Ki-67 were not significantly correlated with the expression levels of ER and PR.In patients with breast cancer with ABCG2 negative and Ki-67 positive,neoadjuvant chemotherapy was more sensitive than other ABCG2 and Ki-67.