Study On The Sensitivity And Risk Factors Of Peripheral Chemosensors In Patients With Obstructive Sleep Apnea-hypopnea Syndrome

Objective: To study on the sensitivity of peripheral chemosensors in patients with obstructive sleep apnea-hypopnea syndrome and its risk factors.Methods: Twenty-eight OSAHS patients in our hospital from July 2018 to February 2019 were randomly selected as the case group,and 12 healthy persons as the control group.The general data of the subjects and the results of sleep monitoring were recorded,and the results of hypoxic withdrawal test were passed.The sensitivity of peripheral chemosensors,including gender,age,BMI,neck circumference,smoking,drinking,sleeping posture,history of nasal stenosis,was assessed by giving the subjects less than 20 seconds pure oxygen and calculating the reduction of ventilation(% Δ V.i),including sex,age,BMI,neck circumference,smoking,drinking,sleeping posture,and history of nasal cavity stenosis.Risk factors,such as history of hypertension,the sensitivity of peripheral chemosensors were analyzed by multivariate linear regression.The risk factors affecting the sensitivity of peripheral chemosensors in OSAHS patients were analyzed.Results: The mean sensitivity of peripheral chemosensors in OSAHS patients before sleep was 21.74 ±3.20(%ΔV.i)lower than that in healthy controls(24.30 ±2.85).There was no significant difference between the two groups(p>0.05).The sensitivity of peripheral chemosensors at morning rise was 41.09 ±8.29(%ΔV.i)higher than that of healthy subjects(27.63 ±2.54,p = 0.001,p < 0.05).There was no significant difference between the morning and before sleep in the sensitivity of chemosensory sensitivity in the healthy subjects group(p = 0.0693)p>0.05.Between the morning and before sleep chemosensory sensitivity in the OSAS group(p=0.000)p <0.05,there was a statistically significant difference.The difference between pre-sleep and morning-time in the OSAHS patient group and the healthy subject group was statistically calculated using before sleep as a baseline value.The difference in peripheral chemoreceptor sensitivity between before-sleep and morning-onset in OSAHS patients was 86.87±19.694(Δ% ΔV.i)compared with healthy subjects at 9.43±11.782(p=0.000)p<0.05,and there was a statistically significant difference.Multivariate regression analysis showed that the apnea hypopnea index AHI was a risk factor for peripheral chemosensory sensitivity changes in OSAHS patients(P=0.012);body mass index BMI is a risk factor for changes in sensitivity of peripheral chemoreceptors in OSAHS patients before bedtime.(p=0.041)。Conclusions: There are peripheral chemoreceptor sensitivity abnormalities in patients with OSAHS,peripheral chemosensitivity sensitivity increased in the morning,which may be related to apnea hypopnea index,and peripheral chemoreceptor sensitivity decreased before bedtime,which may be related to body mass index BMI related.