The Effects Of The Power Frequency Magnetic Field To Neural Electric Signals Of Rats Performing Working Memory

With the rapid development of China's power industry,power frequency electromagnetic field is more and more widely exposed in daily life and work environment,and the exposure intensity is also becoming stronger and stronger.At present,many studies have shown that exposure to extremely low frequency magnetic field and occupation of brain cognitive dysfunction(such as Alzheimer's disease etc.)has a certain correlation with the occurrence probability,which makes the electromagnetic effects on brain cognitive function has become a new research hotspot in twenty-first Century.Working memory is not only an important manifestation of brain cognitive function,but also an important indicator of the function of the nervous system.In recent years,the emerging in vivo multi-channel recording technology,through implantable multi-channel microelectrode array can be used to acquire and record nerve electrical signals in rats during the working memory task.With the in vivo multi-channel recording technology,the effect of the exposure of power frequency magnetic field on the working memory of rats can be carried out from the point of view of the electrical signal.Therefore,the paper will take advantage ofthe in vivo multi-channel recording technology,to research the effect of power frequency magnetic field exposure on the neural electrical signals of the adult SD(Sprague-Dawley)rats on cognitive function from the perspectiveof electrophysiological signals,the main research work includes the following aspects:1.Preparation of rats exposed to power frequency magnetic field model and implanted multichannel microelectrode array.according to the different exposure time,make the experimental group of rats exposed by power frequency magnetic field to get the rats in the model group;by surgery,the implantable multichannel microelectrode array implanted in each rats prefrontal cortex,and the rat's neural electrical signals can be acquired.2.Perform T maze training on rats,statistical behavior correct rate,performing working memory task after rats learned it,at the same time,through in vivo multi-channel recording system,nerve electrical signals in rat prefrontal cortex were acquired and recorded,the Local Field Potential(LFPs)was obtained when the rats performed brain cognitive activity.3.Use the method of time-frequency to analysis of LFPs signals in rats,comparative analysis the peak energy changes and trends of single channel,theta band(4-12Hz),gamma band(30-100Hz)and 16 channels of the rats,results show that long-term exposure to power frequency magnetic field has no significant effect of signal peak changes and trends changes of LFPs working memory in rats,but enhance the activity intensity of theta band and gamma band in rat's LFPs signals.This paper is based on the in vivo multi-channel recording technology,use the method of time-frequency analysis,research and analysis the effect of power frequency magnetic field exposure on rats performing working memory tasks,found that the long-term effects of power frequency magnetic field will strengthen the activity theta band and gamma band in rat's LFPs signals,and combine the behavior statistics,found that the long-term effects of power frequency magnetic field has negative effects on rat's brain cognitive function.