| Objective:This research through the observation of Subclinical Hypothyroidism during pregnancy effects on pregnancy outcomes and the fetus,and assess whether the drug treatment can improve the pregnancy outcome,to provide a reference for our clinical post-treatment.Methods:Selecte 2015.01-2017.02 months in Affiliated hospital of Taishan medical university delivery and early pregnancy screening thyroid functionand.All the data according to the diagnostic2011 ATA enacted "pregnancy and postpartum thyroid treatment guidelines" Pregnancy TSH recommend below as a reference value:(0.1-2.5mIU/L during early pregnancy,the middle of a pregnancy was 0.2-3.0mIU/L;Late pregnancy 0.3-3.0mIU/L,because FT4 normal reference value are greatly influenced by the region,ATA in 2011 in the guide did not give the absolute reference range.The diagnostic criteria for gestational SCH:(10mU/L>TSH>2.5mU/L)(the early stages of pregnancy,TSH>3.0mU/L(middlelate pregnancy),and FT4 in normal reference value range.Conform to the conditions of 66 patients as observation group,With the approval of the hospital ethics committee and informed consent signed informed consent is patients with treatment or not.Pregnancy SCH without treatment group 32 cases,pregnancy SCH treatment group 34 cases,strictly in accordance with the statistical methods in the same period were randomly selected 50 cases of normal thyroid function of pregnant women as normal control group.Analyzed three groups pregnant women production mode and pregnancy outcomes(gestational hypertension disease,premature delivery and gestational diabetes,abnormal amniotic fluid,premature rupture of membranes,postpartum hemorrhage,fetal distress)and fetal adverse outcomes(deformity,stillbirth or low birth weight,fetal mild or severe asphyxia).Result:1.Subclinical Hypothyroidism treatment group cesarean section rate was significantly higher than SCH with treatment group and the normal group,and the difference was statistically significant(P<0.05).SCHwith treatment group and the normal group,compared no significant differences(P>0.05).2.SCH untreated group of pregnant women with SCH treatment group compared with normal group,the incidence of the gestational hypertension,gestational diabetes,premature rupture of membranes,preterm birth,abnormal amniotic fluid aresignificantly higher,the incidence of fetal distress and statistically significant difference(P<0.05).except the postpartum hemorrhage group.3.SCH treatment group compared with normal thyroid function of pregnant women,the gestational hypertension,gestational diabetes,premature rupture of membranes,preterm birth,the incidence of abnormal amniotic fluid and fetal intrauterine distress also increased,but there was no statistically significant difference(P>0.05).4.The incidence of total adverse pregnancy outcomes in the untreated group was higher than that in the SCH with treated and normal groups,but there was no significant difference(P>0.05).The incidence of total adverse pregnancy outcome in SCH after drug therapy compared with normal control group,the difference had no statistical significance(P>0.05).Conclusion:Subclinical Hypothyroidism in pregnancy may have adverse effects on pregnancy outcome.early detection,early diagnosis,early aggressive treatment can effectively reduce complications during pregnancy,further improve the pregnancy outcome,to ensure that the parent and offspring health,provide reference for further clinical treatment. |
