Relationship Between Pretreatment Neutrophil-to-lymphocyte Ratio And Prognosis Of Nasopharyngeal Carcinoma

Objective: To explore the correlation between neutrophil-to-lymphocyte ratio and the prognosis of nasopharyngeal carcinoma,and to evaluate its role in predicting the risk of death and disease progression in nasopharyngeal carcinoma.Method: The patients diagnosed with NPC were collected retrospectively,and NLR was calculated based on the blood routine data before treatment,together with age,UICC / AJCC stage,T stage,N stage,neutrophil count,and lymphocyte count Observation indicators for this study.Kaplan-Meier method and log-rank test were used to calculate and compare survival results,and Cox proportional hazards model was used for multivariate analysis.Results:A total of 142 patients who were treated in the First Affiliated Hospital of Xinjiang Medical University from January 2010 to December 2014 were collected.Taking the total survival time(OS)as the end point and the progression-free survival time(PFS)as the end point,the cut-off value of NLR determined by the receiver operating characteristic curve is 3.50.Within 5 years,the OS of patients with NLR ≥ 3.50 was significantly lower patients with NLR <3.50(P = 0.000,95% CI = 2.88-8.55,HR = 4.96);patients with NLR≥3.50 had significantly lower PFS than patients with NLR <3.50(P =0.000,95% CI = 1.90-6.63,HR = 3.55).Conclusion: This study found that NLR is an independent influencing factor of OS and PFS before treatment.NLR has important clinical significance for the prognosis of NPC.