The Relationship Between ACTA2 And CYP2A13 Gene Polymorphism And Aortic Dissection

Objective: This study was to investigate the association of TGFβ(transforming growth factor-β)pathway-related genes ACTA2(α-smooth muscle actin)and CYP2A13(cytochrome oxidase 2A13)polymorphism with Debakey type Ⅲ AD(aortic dissection)in Chinese Han population.Methods: a case-control study was conducted in 157 cases of aortic dissection Debakey Ⅲ,and 323 cases in the control group without angiography.Real-time PCR was used to identify genotypes of 6 sites of ACTA2(rs2119685,rs3781211,rs2028493)and CYP2A13(rs3968432,rs1645694,rs34178072),and the case group was followed up for 2 years to analyze the occurrence and prognosis of type Ⅲ AD.Results: There were differences in the genotype and allele frequency distribution of ACTA2(rs2119685)between the case group and the control group(P<0.05).After adjusting for confounding factors,logistic regression analysis showed that the association between ACTA gene polymorphism and type Ⅲ aortic dissection was associated(OR=0.369,95%CI:0.202-0.672,p=0.001).In the 2-year follow-up of the case group,the mortality distribution of the ACTA2(rs2119685)dominant model(TTvs.TC+CC)in Debakey type Ⅲ AD patients was statistically significant(P<0.05).Conclusion:The ACTA2(rs2119685)gene polymorphism in Chinese Han population is associated with the occurrence and prognosis of Debakey type Ⅲ AD.The five sites of ACTA2(rs3781211,rs20284933)and CYP2A13(rs3968432,rs1645694,rs34178072)are not associated with Debakey type Ⅲ AD.The results of this study provide reference value for screening and prognosis assessment of Debakey type Ⅲ AD patients.