Clinical Research Of Zengye Runchang Prescription In Treating Functional Constipation With The Lack Of Fluid And Blood

Objective:The purpose of this study was to observe the clinical efficacy of Zengye Runchang prescription in the treatment of functional constipation with low blood deficit in tianjin,as well as the content changes and safety of substance P(SP)and 5-HT(5-HT),so as to provide objective clinical basis for the treatment of functional constipation with low blood deficit in tianjin in the future.Methods:In this study,a total of 60 patients in the department of spleen and stomach diseases and related departments of Suzhou hospital of traditional Chinese medicine affiliated to nanjing university of Chinese medicine were randomly divided into treatment group and control group,with 30 patients in each group.The treatment group was treated with Zengye Runchang prescription,while the control group was treated with moxabilie citrate tablets for 4 weeks.At the end of the treatment course,the patients’ symptom rating scale,clinical efficacy,quality of life scale(PAC-QOL scale),SP and 5-HT level expression and safety indexes were observed before and after treatment.SPSS 26.0 software was used for statistical processing of the experimental data.Results:(1)Individual symptoms were statistically significant difference before and after treatment the two groups(P<0.01),in the stool stem node,defecation time interval,less difficult defecation,dry mouth and Zimbabwe on the performance comparison between the two way difference had statistical significance(P<0.01),on dizziness,lip color light performance comparison between the two way difference had statistical significance(P<0.05),in body weight,less sleep,heart palpitations,performance comparison between the two way difference had no statistical significance(P>0.05),explain in stool stem node,defecation time interval,less difficult defecation,dry mouth,dizziness,tianjin,oral color light symptoms improved treatment group was superior to control group,The effect of the two groups was similar in terms of body emaciation,less sleep,and improvement of palpitation symptoms.The difference of the total score of main disease in the two groups before and after treatment was statistically significant(P<0.01),and the difference between the two groups after treatment was statistically significant(P<0.01),indicating that the total score of main disease in the treatment group was better than that in the control group.The difference of the total score of secondary symptoms in the two groups before and after treatment was statistically significant(P<0.01),and the difference between the two groups after treatment was statistically significant(P<0.01),indicating that the total score of secondary symptoms in the treatment group was better than that in the control group.The difference of total symptom score between the two groups before and after treatment was statistically significant(P<0.01),and the difference between the two groups after treatment was statistically significant(P<0.01),indicating that the total symptom score of the treatment group was better than that of the control group.(2)In terms of clinical efficacy,the total effective rate of the treatment group was 90%,and that of the control group was 70%.The difference in the total effective rate between the two groups was statistically significant(P<0.05),indicating that the clinical efficacy of the treatment group was better than that of the control group.(3)In terms of the total score of the quality of life scale,there were statistically significant differences between the two groups before and after treatment(P<0.01),and statistically significant differences between the two groups after treatment(P<0.01),indicating that the treatment group was superior to the control group in the improvement of the total score of the quality of life scale.(4)In terms of SP level,the level of both groups increased after treatment,and the difference between the two groups before and after treatment was statistically significant(P<0.01).The difference between the two groups after treatment was statistically significant(P<0.05),indicating that the treatment group was superior to the control group in regulating SP level expression.(5)In terms of the expression of 5-HT,the level of both groups increased after treatment,and the difference between the two groups before and after treatment was statistically significant(P<0.01).The difference between the two groups after treatment was statistically significant(P<0.01),indicating that the treatment group was superior to the control group in regulating the expression of 5,HT.(6)During the treatment,there were no adverse reactions in the two groups,indicating safety.Conclusions:Zengye Runchang prescription has significant clinical efficacy in the treatment of functional constipation with deficiency of fluid and blood.It can effectively improve the symptoms of constipation,improve the quality of life of patients,and improve the expression level of SP and 5-HT in patients,and is safe.