Clinical Study On The Effect Of Compound Sheilong Capsule On The Treatment Quality Of IgA Nephropathy

Objective:Through the clinical study on the treatment of IgA nephropathy with dampness-heat stasis with sheilong capsule,the effect of compound sheilong capsule on reducing proteinuria and urinary red blood cell number was observed,the short-term and long-term efficacy of traditional Chinese medicine and western medicine was observed,and the safety of this drug in the treatment of IgA nephropathy was studied.Methods:Using randomized,parallel,control principle,according to the included 72 cases eliminate standards will conform to the hot and damp stasis resistance syndrome patients were randomly divided into treatment group and control group,treatment group patients give compound snakes and capsule,4 / time,3 times/day,control group patients to ambrette capsule,4 / time,3 times/day,and two groups of patients’ antihypertensive,lipid and diuresis detumescence foundation treatment,two groups are two courses of treatment,each course of 12 weeks,for the treatment of 12 weeks and 24 weeks JinYuanQi curative effect evaluation.To judge the laboratory index and clinical efficacy,and to analyze the near and long term clinical efficacy of compound shelong capsule in the treatment of IgA nephropathy.Results:The experimental group was compared with the experimental group at week0,week 12 and week 24.Laboratory indicators included 24-hour urinary protein quantification and urinary erythrocyte sediment.The laboratory indexes were compared before and after 0 weeks,12 weeks and 24 weeks,and the statistical differences were significant before and after treatment.The clinical efficacy of traditional Chinese medicine is based on the standard of guiding principles for clinical research of new traditional Chinese medicine(2002)issued by the central administration of medicine.The clinical efficacy of western medicine was evaluated by referring to the evaluation standard of clinical diagnosis and treatment guide-nephrology and combining with this study.They were compared at 0 weeks,12 weeks and 24 weeks after treatment.The total effective rate was 73.3% in the treatment group and 63.2% in the control group at 12 weeks.At 24 weeks,the effective rate was 86.67% in the treatment group and66.67% in the control group.P < 0.05 was statistically significant in the 12-week treatmentof TCM.P < 0.05 after 24 weeks was statistically significant.In addition,clinical safety studies were conducted on the safety indexes of blood routine,liver function and blood kidney function.Conclusion:As far as the current comparison is concerned,the compound sheilong capsule has no effect on the liver and kidney function of the patients,indicating its safety.In terms of its dehydrating protein and urinary sediment erythrocytes,it can play a role within 12 weeks,and the effect at 24 weeks is significantly higher than that at 12 weeks.By comparing the clinical efficacy of traditional Chinese medicine and western medicine,it also indicates that the efficacy at 24 weeks is significantly better than that at 12 weeks,indicating that the efficacy is positively correlated with the course of treatment.