| Objective:To evaluate the efficacy and safety of Ruyi Jinhuang powder in the treatment of papulopustular rosacea(PPR)through clinical research,and provide a theoretical basis for extensive clinical application.Furthermore,it can provide effective,safe and economical Chinese medicine external preparation for the clinical treatment of PPR.Methods: Ninety patients with PPR diagnosed in the outpatient department of the Hospital were divided into three groups(A,B and C)according to the table of random Numbers,with 30 cases in each group.Group A: Ruyi Jinhuang powder external application;Group B: Metronidazole gel for external use;Group C: Honey external application,all three groups were given oral doxycycline hydrochloride enteric-coated capsules,100 mg / d.A total of 8 weeks of clinical observations were performed on this topic,and 4 weeks was a course of treatment.Clinical efficacy was observed at weeks 0,4,and 8.The clinical symptoms score and skin barrier function physiological index were recorded.Adverse reactions were also recorded.Result:1.Baseline data: There were no statistical differences in demographics(age composition,sex ratio,duration of disease,and occupation)and the factors that induce and exacerbate the disease(drinking,smoking,stress,sleep,etc.)in the three groups(P> 0.05).2.Clinical efficacy judgment:2.1 After completing the 8-week treatment,4 patients were cured,including 3 in group A and 1 in group B;Among the 55 cases with marked effect,the A,B,and C groups were 21,19,and 15 respectively.The total effective rates of groups A,B,and C were80.0%,66.7%,and 50.0%,respectively.The total effective rate of group A was significantly higher than that of groups B and C,the difference in efficacy among the three groups was statistically significant(P <0.05).2.2 Comparison of the total score of clinical symptoms:There was no statistical difference in the total scores before treatment among the threegroups(P> 0.05);Comparison of the total score and the total treatment efficiency of the three groups: There was a significant statistical difference between the three groups(P<0.01),and the A group was better than the B and C groups.2.3 Comparison of clinical observation indicators:2.3.1 Comparison of erythema and papule pustules score: The comparison among the three groups was statistically significant(P<0.05).Pairwise comparisons between groups: The differences between groups A and B were statistically significant(P<0.05),as well as groups A and C.2.3.2 Comparison of telangiectasia,burning,prickling,itching and drying score: There was no statistical difference among the three groups(P>0.05);The time factors of the three groups were statistically different(P<0.05),that is,the scores gradually decreased with the treatment time.2.4 Comparison of parameters related to skin barrier function:8weeks after treatment,the comparison of stratum corneum hydration among the three groups was statistically significant(P<0.05).Pairwise comparisons between groups:The difference between groups A and C was statistically significant(P<0.05).Trans-epidermal water loss(TEWL),p H and erythema index: showed significant difference in time factors(P<0.05),There was no significant difference among the three groups(P>0.05).Sebum level: No significant difference was found among the three groups or the time factor of the three groups(P> 0.05).2.5 Adverse: One patient in group A itching worsens due to incorrect use of Ruyi Jinhuang powder.However,after proper use,the adverse reactions disappeared.After using metronidazole gel in 3 patients in group B,the skin itching was more severe than before.After reducing the dose,the symptoms disappeared.Conclusion:The clinical efficacy of external application of Ruyi Jinhuang powder in improving the clinical symptoms in patients with PPR is better than that of honey group and better than metronidazole gel group.The operation that applying Ruyi Jinhuang powder to theskin lesions is simple,convenient,economical,and safe without adverse reactions.It can be widely used in clinical practice. |
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