Retrospective Clinical Observation On Integration Of Traditional And Western Medicine Of CVA Of Wind Chill Clamp Sputum Syndrome Based On Data Mining

Objective 1.To clarify the core components and core drugs of CVA treated by traditional Chinese medicine in the past fivey ears,for reference and comparison in the follow-up study.2.To clarify the clinical effect of CVA treated by the integratio n of Traditional and Western medicine(combination of Juanxiao Zhike prescription and Montelukast sodium tablets),by resear ching retrospective study of clinical cases.3.To clarify the clinical effect and rationality of Juanxiao Zhike prescriptio n,to reasearch the syndrome differentiation and treatment of CVA of Wind Chill Clamp Sputum Syndrome,and to broadenthe cl inical treatment path.Methods It's divided into two parts:1.Retrospective collecte d the literature of CVA treatment in the past five years,Usin g the ancient and modern medical case network platform to exp lore the drug law,summarized the core prescriptions and cored rugs,for reference and comparison in the follow-up study.2.Us ing methods of retrospective investigation,collecting of medi cal records of Hubei Provincial Hospital of Traditional Chine se Medicine from January 2015to January 2020,screening of 60cases that met inclusion and exclusion criteria.According to different treatment methods and contents of the records,medic al records are divided into two groups,30 cases per group.G roup I(experimental group):Medical records of treatment wi th Juanxiao Zhike prescription and Montelukast sodium tablets;Group II(control group):Medical records of Montelukast so dium tablets alone.Adopting SPSS22.0 Statistical to analysis,the difference of curative effect between the two groups wassummarized by comparing TCM symptom score,EOS count,FeNO,Pul monary function(FVC,FEV1/FVC,PEF average mutation rate).Result A total of 370 literatures were included,involving 174 kinds of drugs.The high-frequency drugs were:licorice,ephed ra,almond,pinellia ternate,periostracum cicadae,balloonflower.The four Qi were mainly warm property,ping nature and cold ab scess,the five flavors were mainly pungent herbs,bittering a nd Gan Taste,the Meridian tropism were mainly lung,spleen and stomach,the efficacy was mainly for relieving sore throat,he at-clearing and detoxifying,induce diuresis to alleviate edem a.The drug combinations with strong correlation were“asarum,ephedra”,“asarum,pinellia ternate”,“Earthworm,ephedra”,th e core prescription composition is:ephedra,almond,balloonflow er,periostracumcicadae,aster,schisandrachinensis,earthworm,p inellia ternate,licorice.2.Of the 60 cases included:46.7%ma les and 53.3%females;the age was between 20-61;BMI was betwe en 18.07-26.37 kg/m~2;onset months were concentrated in October-December;the course of disease was 74-132 days;50.0%patient s had history of allergic diseases.There was nostatistical si gnificant difference between the two groupsbefore treatment(P>0.05),with comparability;there were statistically signific ant differences in EOS count,FeNO,TCM symptom score and pulmo nary function index between thetwo groups after treatment(P<0.05):the total effective rate of the experimental group was 90.0%,and that of the control group was 76.7%;the totalsymptom score of the experimental group after treatment was 2.48±1.90,and that of the control group was 5.01±2.46;the total EO S count of the experimental group after treatment was 0.41±0.06×109/L,and that of the control group was 0.41±0.06×109/L,the FeNO of the experimental group after treatment was 17.10±4.57ppb,and that of the control group was 20.33±6.45ppb;t he FVC of the experimental group was 3.49±0.73l,and thatof t he control group was 2.88±0.54l;the FEV1/FVC ofthe experimen tal group was 82.87±5.02%,and that of the control groupwas 79.26±4.23%;the PEF average mutation rate of the experimental group was 7.97±0.86%,and that of the control group was 8.39±0.59%;the adverse reaction rate of the experimentalgroup was 3.3%,and that of the control group was 16.7%(P<0.05).Ev ery safe index was normalin two group.Conclusion 1.The traditional Chinese medicine treatment of C VA is mostly use 0f warm medicine,which is closely related to the lung and spleen.Attach importance to diaphoresis relievin g superficies and kiyosato,dispelling wind and relieving sor ethroat,and assisted with clearing away heat and dispersing l ung,strengthening spleen and benefiting vital qi,powder stasi s and pass collaterals.2.The curative effect of JuanXiao ZhiK e Prescription combined with Montelukast sodium tablets in th e treatment of CVA is significantly better than that of Weste rnmedicine alone,which can obivously reduce the incidence of adverse reactions and the risk of recurrence;3.JuanXiao ZhiKe Prescription has definite curative effect in the treatment o f CVA,which is in line with the Syndrome differentiation and drug law of clinical treatment of CVA.