| Objective:1.To study the relationship between homocysteine(Hcy),Lipid peroxide(LPO)and hypertension.2.To explore the relationship between Hcy,LPO and left ventricular hypertrophy(LVH).Methods:A total of 398 patients were selected as hypertensive patients hospitalized in the Department of Cardiology of Hainan General Hospital from April 2019 to November 2019 and healthy people who had physical examinations in the hospital during the same period.All subjects were tested for blood pressure and cardiac echocardiography.A retrospective research method was used to divide 192 patients into hypertension group and 206 normal control group based on whether they had hypertension or not.In the hypertension group,according to the left ventricular mass index(LVMI),it was further divided into a simple group of 103 cases and a complication group of 89 cases.The data about the general clinical and biochemical indicators of all cases were collected.Hcy level was detected by cyclic enzyme kinetics method.The level of malondialdehyde(MDA)which reflect the LPO level was measured by thiobarbituric acid method.The data of Hcy and MDA levels of the three groups were analyzed and compared.The correlations between Hcy and blood pressure and LVH were analyzed;the correlations between MDA and blood pressure and LVH were analyzed also.Results:1.The concentrations of Hcy between the three groups from high to low were complication group,simple group,control group,and there was statistically significant difference between the three groups(P <0.05).2.The concentrations of MDA between the three groups from high to low were complication group,simple group,control group,and there was statistically significant difference between the three groups(P <0.05).3.Logistic regression analysis showed that Hcy was positively correlated with hypertension(OR =6.313 P<0.001),and MDA was positively correlated with hypertension(OR =3.289,P<0.001).4.Linear regression analysis showed that Hcy was positively correlated with Systolic Blood Pressure(SBP)and Diastolic Blood Pressure(DBP)(P <0.05),and MDA was positively correlated with SBP and DBP(P <0.05).5.There was no statistical difference between the left ventricular end diastolic dimension(LVEDD)index of the simple group and the complication group(P>0.05).The LVEDD of the simple group and the complication group were higher than the control group(P <0.05).The left ventricular posterior wall thickness(LVPWT),interventricular septum thickness(IVST),left ventricular mass(LVM)and left ventricular mass index(LVMI)values of the complication group were higher than the simple group and the control group(P<0.05),the LVPWT,IVST,LVM and LVMI values of the simple group were higher than the control group(P<0.05)6.Logistic regression analysis showed that: Hcy was positively correlated with LVH(OR=2.529,P<0.001),MDA was positively correlated with LVH(OR=2.052,P<0.001),and SBP was positively correlated with LVH(OR=1.156,P<0.05).7.Linear regression analysis showed that SBP was positively correlated with LVMI(P <0.001),Hcy was positively correlated with LVMI(P <0.001),and MDA was positively correlated with LVMI(P =0.001).8.Logistic regression analysis showed that there was synergistic effect between Hcy and MDA on LVM(P<0.001).Conclusion:1.Serum levels of Hcy and MDA levels are related to the risk of hypertension.2.Serum levels of Hcy and MDA levels were positively correlated with SBP and DBP.3.There was a correlation between Hcy,MDA and SBP levels and LVMI,but not no significant correlation was found with DBP.4.Hcy and MDA were positively correlated with LVH,the combined detection of Hcy and MDA can be great significance for early identification of essential hypertension complicated left ventricular hypertrophy. |
PDF Full Text Request