Relationship Of Serum Lp-PLA2 And TSP-1 Levels With The Severity Of Coronary Artery Disease And Short-term Mace Events In Patients With Acute Coronary Syndrome

Objective:To investigate the relationship between serum lipoprotein-asociated phospholipase A₂?Lp-PLA₂?and thrombospondin-1?TSP-1?levels and the degree of coronary stenosis in patients with acute coronary syndrome?ACS?as well as short-term major cardiovascular adverse events?MACE?.Methods:From January 2019 to December 2019,among the patients who had been diagnosed at Loudi Hospital Affiliated to the University of South China and improved related examinations due to chest pain and chest tightness,79 enrolled diagnosed with acute coronary syndrome were included in the experimental group.Twenty-nine patients randomly collected with normal troponin I and myoenzymes at the same period and negative coronary angiography were included in the control group.According to Gensini score,patients with ACS were divided into three coronary lesion subgroups:mild lesion group,moderate lesion group and severe lesion group,including 27 cases in mild lesion group and 26 in moderate lesion group and severe lesion group.Mild lesion group:Gensini Score<41;Moderate lesion group:41?Gensini Score<64;Severe lesion group:Gensini Score?64.All patients with ACS were followed up for three months after discharge and were divided into MACE group and non-MACE group according to the results.The serum Lp-PLA₂ and TSP-1 concentrations of the selected patients were detected by enzyme-linked immunosorbent assay?ELISA?,and all data were summarized for statistical analysis.Results:1.The differences in age,sex,BMI,drinking history,smoking history and creatinine between the experimental observation subgroup and the control group was not statistically significant?P>0.05?;The differences of CTnI and hs-CRP in each group was statistically significant?P>0.05?.2.Comparing the serum levels of Lp-PLA₂ and TSP-1 in the experimental observation subgroup and the control group,it showed that the differences between the control group and the mild lesion group was not statistically significant?P>0.05?,but differences between the rest of all the two adjacent groups was statistically significant?P<0.05?.3.Linear correlation analysis showed a positive correlation between serum Lp-PLA₂ and TSP-1?r=0.595,P<0.001?level and Gensini score?r=0.442,P<0.001;r=0.595,P<0.001?.4.The differences of serum Lp-PLA₂ in the MACE group?1428.69±297.71?ng/ml and the non-MACE group?1223.70±285.93?ng/ml are statistically significant?p<0.05?;the differences of serum TSP-1 in the MACE group?188.47±17.57?ng/ml and the non-MACE group?169.02±33.30?ng/ml also are statistically significant?P<0.05?.5.Areas of serum Lp-PLA₂ and TSP-1 under the receiver operating characteristic?ROC?curve of were 0.701 and 0.704respectively?P<0.05?,which is statistically significant.Conclusion:1.The expression levels of serum Lp-PLA₂ and TSP-1 in patients with acute coronary syndrome may be related to the severity of coronary stenosis.2.The expression levels of serum Lp-PLA₂ and TSP-1 in patients with acute coronary syndrome were increased in MACE group.