Analysis Of The Relationship Between SdLDL And Cardiovascular Risk Factors In Obese Children

Objective:Through the determination of serum small and dense low-density lipoprotein cholesterol(sd LDL-C)in obese children,the correlation between sd LDL and cardiovascular risk factors was analyzed,and the role of sd LDL in the occurrence and development of cardiovascular disease in children was discussed.Method:A total of 56 obese children who underwent physical examination in the Pediatrics Clinic of the first affiliated Hospital of Dalian Medical University from January 2019 to January 2020 were selected,and 75 normal weight children were randomly selected for physical examination in the same period.The 131 children collected recently did not take drugs that affected blood glucose,blood pressure,blood lipids and other drugs,and none of them had heart,liver,kidney and endocrine dysfunction in the past.Secondary obesity caused by endocrine diseases,genetic metabolic diseases and central system diseases were excluded.Grouping standard:1.According to the BMI percentile curve of Chinese children and adolescents aged 0-18 years old,they were divided into obesity group and control group.2.The obese children were divided into three groups according to the body mass index((body mass index,BMI)(first quartile,BMI≤23.38 kg/m~2;second quartile,23.39kg/m~2≤BMI≤25.25 kg/m~2;third quantile,BMI≥25.26kg/m~2).Basic informations,such as sex,age,height,weight and blood pressure(BP)were recorded carefully,and the patients’venous blood was collected in the early morning.The contents of homocysteine(Hcy),uric acid(UA),fasting blood glucose(FBG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)and apolipoprotein B(apo B)were detected by automatic biochemical analyzer.Two milliliter of venous blood were taken and stored in the refrigerator at-80℃.sd LDL-C was detected by small dense low-density lipoprotein detection kit(detected by the biochemical laboratory of the first affiliated Hospital of Dalian Medical University).SPSS21.0 statistical software was used to analyze the clinical data,and P<0.05 means the difference is statistically significant.Result:1.There was no significant difference in age and sex composition between the obesity group and the control group(p>0.05).The BMI in the obese group was significantly higher than that in the control group((24.27±3.55)kg/m~2vs.(16.04±1.72)kg/m~2,p<0.05).2.The level of LDL-C,apo B,TG,FBG,UA,Hcy,SBP and sd LDL-C in the obese group were significantly higher than those in the control group(p<0.05).In term of HDL-C and TC,there was no significant difference between the two groups(p>0.05).3.Pearson correlation analysis or Spearman correlation analysis showed that sd LDL-C level was positively correlated with LDL-C,apo B,TC,TG,UA,Hcy,SBP,BMI and FBG,but negatively correlated with HDL-C(r=0.308、0.372、0.287、0.354、0.337、0.481、0.408、0.531、0.516、0.338、-0.381 respectively,p<0.05).4.56 obese children were divided into two groups according to the third quartile of BMI.There was no significant difference in age and sex between the two groups(p<0.05).With the increase of BMI in obese children,the levels of sd LDL-C,LDL-C,FBG,UA,Hcy,SBP and DBP increased significantly(p<0.05).However,the levels of apo B,TC and TG increased gradually with the increase of BMI,while the level of HDL-C decreased with it,but there was no statistical significance(p>0.05).Only sd LDL-C showed significant change in the index between the second quartile and the first quartile.Conclusion:1.The levels of sd LDL-C,LDL-C,apo B,FBG,UA and BP in obese children were significantly higher than those in the control group.According to the BMI ternary of obese children,the levels of sd LDL-C,LDL-C,apo B,TC,TG,FBG,UC,Hcy and BP were the highest in the third quartile of BMI and the lowest in HDL-C,indicating that obese children have a higher risk of cardiovascular disease.2.Correlation analysis showed that there was a correlation between sd LDL-C and cardiovascular risk factors in obese children.In the comparison between the second quartile of BMI and the first quartile of BMI in obese children,only the level of sd LDL-C changed significantly,indicating that with the increase of obesity,the difference of sd LDL-C appeared earlier,which may be more sensitive than other cardiovascular disease risk indexes,such as blood lipid parameters,Hcy,UA,BP and so on.sd LDL-C may have a certain predictive value for cardiovascular disease in children.