| Objective: To observe the effect of transcutaneous auricular vagus nerve combined with chemotherapy antiemetic on chemotherapy-induced nausea and vomiting(CINV),and evaluate the effect of transcutaneous auricular vagus nerve on chemotherapy-induced nausea and vomiting,and in order to provide new treatment for chemotherapy-induced nausea and vomiting.Methods: All the cases in this study,were from the Department of Oncology and Department of Thyroid and Breast Surgery,the first affiliated hospital of Guangxi University of Traditional Chinese Medicine.Using the random number table method,120 patients who met the inclusion criteria were divided into three groups : the chemotherapy antiemetic control group(simple chemotherapy antiemetic group,referred to as Group A);the observation group(transcutaneous auricular vagus nerve stimulation + chemotherapy antiemetic group,referred to as Group B);the pseudo auricular point stimulation group(pseudo transcutaneous auricular vagus nerve stimulation + chemotherapy antiemetic group,referred to as Group C),40 cases in each group.Before 30 min on the first day of chemotherapy,the chemotherapy antiemetic control group received intravenous infusion of palonosetron 0.25 mg and dexamethasone 10mg;meanwhile,it,on the second and third days of chemotherapy,received intravenous injection of dexamethasone 10 mg.The observation group,on the basis of the chemotherapy antiemeticcontrol group,were stimulated auricular vagus nerve point(auricular point,“esophagus”,“stomach”,“small intestine”): once a day,starting from 2 days before chemotherapy,for a total of 7 days and each stimulation for 30 minutes.On the basis of the chemotherapy antiemetic control group,the pseudo auricular point stimulation group were not stimulated the auricular vagus nerve point with electricity,but given psychological hints(the treatment course with the same as the observation group).Observe 24 hours after the end of the first day of chemotherapy and the 4th day after the end of the first day of chemotherapy(at the end of transcutaneous auricular vagus nerve stimulation treatment)CTCAE4.0 standard nausea and vomiting grade,MAT scale score;FLIE score on the 4th day after the end of the first day of chemotherapy(end of treatment);before treatment,24 hours after the end of the first day of chemotherapy and the 4th day after the end of the first day of chemotherapy(end of treatment)QOL scale score.All experimental data are processed using statistical software SPSS22.0.Results:(1)Nausea and vomiting symptoms: there are,among the three groups on the 24 h and the 4th day after the first day of chemotherapy,significant differences in the degree and frequency of nausea and vomiting(P<0.05).On the 24 h and the 4th day after the first day of chemotherapy,the difference,among the observation group,the chemotherapy antiemetic control group and the pseudo auricular point stimulation group,is statistically significant(P<0.05);the difference,between the chemotherapy antiemetic control group and the pseudo auricular point stimulation group,is not statistically significant(P>0.05).The results showed that the degree of nausea and vomiting in theobservation group were lower than those in the chemotherapy antiemetic control group and the pseudo auricular point stimulation group at 24 h and4th day after the end of the first day of chemotherapy.And the frequency of vomiting in the observation group is lower than the chemotherapy antiemetic control group and the pseudo auricular point stimulation group.(2)The curative effect of nausea and vomiting: there is,on the 24 h and the 4th day after the first day of chemotherapy,among the three groups,statistical difference(P<0.05).On the first day and the fourth day after chemotherapy,the effective rate of the observation group(87.5%,85%),compared with the pseudo auricular point stimulation group(65%,67.5%)and the chemotherapy antiemetic control group(62.5%,65%),is statistically significant(P<0.05),but the difference,between the chemotherapy antiemetic control group and the pseudo auricular point stimulation group,is not statistically significant(P>0.05).The results showed that the effective rate of nausea and vomiting in the acute and delayed phases of the observation group was higher than that of the chemotherapy antiemetic control group and the pseudo auricular point stimulation group.(3)Life function index: there is,at the end of transcutaneous auricular vagus nerve stimulation treatment,statistical difference in the three groups(P<0.05).The difference,among the observation group,the chemotherapy antiemetic control group and the pseudo auricular point stimulation group,is statistically significant(P<0.05);but the difference,between the chemotherapy antiemetic control group and the pseudo auricular point stimulation group,is not statistically significant(P>0.05).The results showed that the observation group had a lower influence onthe patients’ life function index than those in the chemotherapy antiemetic control group and the pseudo auricular point stimulation group.(4)Quality of Life: QOL scores of the three groups,before treatment,has no statistical difference(P>0.05),which is comparable.The three groups of patients’ QOL scores,via repeated measurement data analysis and pairwise comparison before treatment(D0),on the 24 h after the end of the first day of chemotherapy(D1)and the 4th day after the end of the first day of chemotherapy(D4),suggests that the difference,among the observation group,the chemotherapy antiemetic control group and the pseudo auricular point stimulation group,is statistically significant(P<0.01);while the difference,between the chemotherapy antiemetic control group and the pseudo auricular point stimulation group,is not statistically significant(P>0.05).The results showed that the quality of life of the observation group after treatment was higher than that of the chemotherapy antiemetic control group and the pseudo auricular point stimulation group.Conclusion: Transcutaneous auricular vagus nerve stimulation combined with chemotherapy antiemetic is better than pure chemotherapy antiemetic in prevention and treatment of CINV.It can effectively improve acute CINV and delayed CINV,thereby reducing the impact of nausea and vomiting on patients’ life function index and improving the quality of life,so it’s worthy of further promotion. |
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