Clinicopathological Characteristics And Survival Analysis Of Male Breast Cancer And Postmenopausal Female Breast Cancer Patients

Objective: 1.Compare the clinicopathological characteristics of male breast cancer with pre-menopausal female breast cancer.2.Compare the 5-year overall survival rate of male breast cancer with pre-menopausal female breast cancer.3.Study the prognostic factors of male breast cancer.Method:We collected 50 cases of MBC patients without distant metastasis who were diagnosed as breast cancer by surgical pathology from January 1,2010 to December 31,2014,and were treated at the Cancer Hospital Affiliated to the Third Clinical Medical College of Xinjiang Medical University.Group(group M),512 patients without distant metastasis were selected from 6554 patients with FBC admitted to the hospital during the same period as the control group.The control group was divided into premenopausal group(group A,N = 251)and postmenopausal group(group B,N = 261).The two groups and Fisher’s exact probability method were used to compare the clinicopathological characteristics of the three groups of patients.The survival analysis and survival curve were drawn by Kaplan-Meier estimation method.,3stages and age were matched with MBC group for propensity scores to correct confounding factors,and then Cox regression analysis was performed.p <0.05 has statistical significance.Results:1.The male group and the premenopausal group: the differences in patient age(2 = 31.176,p≤0.001),ER(2 = 15.504,p <0.001),Her-2(2 =14.670,p <0.001)were statistically significant.Male group and post-menopausal group:There was a statistically significant difference in ER among patients(2 = 6.510,p = 0.011).2.The 5-year survival rate of male breast cancer patients is 62.0%,female breast cancer patients is 76.6% in postmenopausal group,and female breast cancer patients is premenopausal group is 66.5%.The 5-year survival rate of male breast cancer patients was not statistically different from that of female pre-menopausal women(p = 0.268),butit was statistically different from that of female post-menopausal women(p = 0.005).3.In groups M and B: postmenopausal FBC patients have higher OS than MBC patients(OR =0.180,p = 0.000);stage(OR = 0.312,p = 0.000),ER(OR = 19.677,p = 0.000)and Her-2status(OR = 2.099,p = 0.022)is the influencing factor of OS prognosis.In the M1 and B1groups: the OS of FBC after matching is higher than that of the MBC group(HR = 0.135,p = 0.000);the stage(HR = 0.098,p = 0.000)and ER status(HR = 7.538,p = 0.016)are Factors affecting OS prognosis.Conclusion:1.In this group of data,male breast cancer is mainly stage I;male breast cancer patients and premenopausal patients have large differences in clinicopathological characteristics,and there are obvious differences in age,ER,Her-2,male breast Cancer patients showed a higher ER positive rate and a lower Her-2 positive rate,and were mainly aged ≥ 40 years old.Male breast cancer patients and postmenopausal groups have similar clinicopathological characteristics,but male breast cancer has a higher ER positive rate than postmenopausal groups.2.The 5-year survival rate of male breast cancer patients is 62.0%,female breast cancer patients is 76.6% in postmenopausal group,and female breast cancer patients is premenopausal group is 66.5%.The 5-year survival rate in the male group is similar to that in the premenopausal group and lower than that in the postmenopausal group.3.Staging and ER status are factors that influence the prognosis of OS.