| Objective Through clinical observation of stilbene even sensitization pa rties inpatients with polycystic ovary syndrome(PCOS)polycysticovaria nsyndrome,insulin resistance and the influence of the serum levels of c hronic inflammation factors and the clinical efficacy of the treatment,to guide the clinical treatment of patients with polycystic ovary syndrome to add new treatments.Methods Sixty-four subjects with spleen-deficiency,phlegm-dampness-type polycystic ovary syndrome(pcos)who met the inclusion criteria were collected and divided into the control group and the treatment group,32 patients in the control group and 32 patients in the treatment group.The control group was treated with metformin hydrochloride orally,and the treatment group was treated with traditional Chinese medicine qi lian zengmin fang on the basis of the control group.Two groups were treated continuously for 3 menstrual cycles(one menstrual cycle was 28 days).After the treatment,compared two groups of patients before and after treatment serum luteinizing hormone(LH),Follicle stimulating hormone(FSH),luteinizing hormone and follicle-stimulating hormone(LH/FSH)ratio,total testosterone(T),hypersensitive c-reactive protein(hs CRP)and interleukin 6(IL-6),tumor necrosis factor alpha(TNF-?),fasting plasma glucose(FPG),fasting insulin(FINS),insulin resistance index(HOMA IR),average volume of ovaries,body mass index(BMI),the change of clinical symptom integral,acne integral,analysis of two groups of clinical comprehensive curative effect.Results1.Comprehensive clinical efficacy: the total effective rate was 86.67% in the treatment group and 86.67% in the control group63.33%,the difference between groups was statistically significant(P < 0.05).2.TCM syndrome score and acne score: After treatment,TCM symptom score of both treatment group and control group decreased compared with that before treatment,the difference was statistically significant(P < 0.05),and the difference between groups was statistically significant(P < 0.05).After treatment,the acne scores of both the treatment group and the control group were lower than that before treatment,with statistically significant differences(P < 0.05),and statistically significant differences between the groups(P < 0.05).3.Sex hormones: after treatment,LH,LH/FSH and T in both groups decreased compared with that before treatment,and FSH increased compared with that before treatment,with statistically significant difference(P < 0.05).After treatment,there were statistically significant differences in LH,LH/FSH and T between the two groups(P < 0.05),while there were no statistically significant differences in FSH between the two groups(P > 0.05).4.Insulin levels and BMI: after treatment,compared with those before treatment,the differences between the two groups were statistically significant(P < 0.05).After treatment,there was no significant difference in FPG between the two groups compared with that before treatment(P > 0.05).After treatment,compared among groups,FINS and HOMa-IR showed statistically significant differences(P < 0.05).After treatment,there was no significant difference in FPG between groups(P > 0.05).After treatment,BMI of the two groups was lower than that before treatment,with statistically significant difference(P < 0.05),while there was no statistically significant difference between the two groups(P > 0.05).5.Inflammatory factors: After treatment,h S-CRP,IL-6 and TNF-in the two groups were all lower than before treatment,and the differences between the two groups were statistically significant(P < 0.05).6.Average ovarian volume comparison: after treatment,the ovarian volume of both groups decreased compared with that before treatment,with statistically significant difference(P<0.05),and statistically significant difference between the two groups(P<0.05).Conclusions1.Qilian zengmin prescription can effectively improve the clinical symptoms such as loose menstruation and acne and improve the quality of life of PCOS patients with spleen deficiency and dampness.2.Qilian zengming formula can effectively improve insulin resistance and sex hormone level in PCOS patients with spleen deficiency and phlegmdampness syndrome,which may be related to the reduction of serum hs-crp,il-6 and tnf-pcr levels in patients,and its mechanism remains to be further studied.3.Qilian zengmin prescription for the treatment of spleen deficiency and dampness-sheng polycystic ovary syndrome patients with positive efficacy,low price,no obvious side effects,safe use,worthy of clinical promotion. |
PDF Full Text Request