Clinical Observation Of Self-made Shugan Jianpi Prescription In The Treatment Of Functional Dyspepsia Of Liver Depression And Spleen Deficiency

Objective: Clinical symptoms,mental state,quality of life and recurrence of FD patients were observed before and after treatment,compared with simple western medicine,this paper evaluates the clinical curative effect and safety of self-made Shuganjianpi prescription in the treatment of FD,and provides theoretical basis for the treatment of FD traditional Chinese medicine.Methods: Sixty patients who met the FD diagnostic criteria were randomly divided into 30 patients in the treatment group and 30 patients in the control group by random digital table.The treatment group was treated with self-made Shugan Jianpi prescription,the control group was treated with mosapride citrate dispersible tablets and lansoprazole enteric-coated tablets.The course of treatment in both groups was 4 weeks.Observe the overall clinical effect after treatment,the total score of TCM symptoms before and after treatment,the single TCM symptom score,mental state,quality of life,recurrence and adverse reactions,carry out comparative analysis,statistical data,draw a conclusion.Results: A total of 3 cases were excluded,and a total of 57 cases were finallyinvolved in the statistics,including 29 cases in the treatment group and 28 cases in the control group.⑴Clinical comprehensive efficacy comparison: the total effective rate of the treatment group was 93.10%,the total effective rate of the control group was75.00%,and the total effective rate of the treatment group was better than that of the control group(P<0.05).⑵Comparison of TCM symptom score: the total score of TCM symptom after treatment and total score before treatment were obviously different between the two groups(P<0.05).The total score of TCM symptoms in the treatment group after treatment was significantly better than that in the control group(P<0.05).⑶ Single TCM symptom score comparison: The symptom scores of the treatment group after treatment were lower than those before treatment(P<0.05).In the control group,there was no significant difference between symptom score and pre-treatment in the treatment of irritability,insomnia,dreams and fatigue(P>0.05).Both the remaining symptom score and the pre-treatment contrast were significantly different(P<0.05).The symptom scores of the treatment group after treatment were lower than those of control group(P<0.05).⑷Mental state comparison: There were significant lower in SAS and SDS scores between the two groups after treatment compared with those before treatment(P<0.05).The SAS score and SDS score of the treatment group aftertreatment were significantly lower than those of the control group(P<0.05).⑸Quality of life comparison: the total quality of life score of the two groups after treatment was significantly higher than that before treatment(P<0.05).The total quality of life score of the treatment group after treatment was significantly higher than that of the control group(P<0.05).⑹Comparison of recurrence: The recurrence rate of the treatment group was7.41%,the control group was 33.33%,and the recurrence rate of the treatment group was lower than that of the control group(P<0.05).⑺Safety analysis: the safety indexes of the two groups were not abnormal before and after treatment.No adverse reactions occurred during treatment.Conclusions: The self-made Shuganjianpi prescription is effective in the treatment of patients with functional dyspepsia of liver depression and spleen deficiency.It can obviously relieve the clinical symptoms of the patients,improve the anxiety and depression state of the patients,significantly improve the quality of life of the patients,at the same time,the safety is better,the recurrence rate is low,and it is worth further popularizing and using.