Study On The Relationship Between TCM Syndromes And Thyroid Function Of Hashimoto's Thyroiditis Complicated With Nodules

PurposeThrough the collection of clinical data,to explore the correlation between TCM syndrome type and thyroid function in patients with Hashimoto's thyroidit is and thyroid nodules,so as to provide a basis for early prevention and treat ment of thyroid diseases and better serve the patients.MethodsThe clinical data of patients with Hashimoto's thyroiditis diagnosed in the Endocrinology Department of Yunnan traditional Chinese Medicine Hospital from November 2018 to January 2020 were collected,including 31 males(19.4%)and 129 females(80.6%).The average age of onset was 48.33±12.38 years old,and the prevalence rate of mental workers was higher than that of manual labor and unemployed workers.The detection indexes included thyroid hormone,thyroid associated antibody and thyroid B-ultrasound.According to the syndrome differentiation of traditional Chinese medicine,the correlation between Hashimoto's thyroiditis with nodules and related indexes was analyzed.Results1.Distribution of TCM syndrome types: Qi depression and phlegm obstruction(27.5%)> qi deficiency with phlegm(23.8%)>phlegm and blood stasis(20.6%)>exuberant liver fire(14.4%)>heart and liver yin deficiency(13.7%).2.There were significant differences between TCM syndrome type and age,TSH,FT4,T3,T4(P<0.05): the youngest was the type of exuberant liverfire,the oldest was the type of deficiency of heart and yin,the mean value of TSHof the type of exuberant liver fire was the smallest,the mean value of T3 and T4 was the highest,the mean value of TSH of qi deficiency with phlegm was the largest,and the mean value of T3 and T4 was the smallest.3.Each syndrome type as the dependent variable(heart and liver yin deficiency,liver fire exuberant,phlegm knot blood stasis,qi deficiency clamp phlegm,qi stagnation phlegm obstruction),with each index as the independent variable(age,TSH?FT4?T3?T4),the binary regression analysis shows that:There was a positive correlation between age and yin deficiency of heart and liver(P<0.05),TSH negative correlation(P<0.05);There was a negative correlation between age,TSH and liver-fire exuberant type(P<0.05),positive correlation(P<0.05);There was a positive correlation between age,T3 and blood stasis type(P<0.05),FT4 negative correlation(P<0.05);TSH was positively correlated with Qi deficiency and phlegm type(P<0.05);T4 negatively correlated with it(P<0.05);There was a negative correlation between age,T3 and qi stagnation and phlegm obstruction(P<0.05).age?TSH?FT4?T3?T4 and five syndromes were correlated.Conclusion1.Among the syndrome types of Hashimoto's thyroiditis with nodules,the most common type was qi stagnation and phlegm stagnation type,followed by qi eficiency with phlegm type.2.Among the TCM syndrome types of Hashimoto's thyroiditis with nodules,the patients with hyperthyroidism were more in the type of exuberant liver fire,and the patients with hypothyroidism were more in the type of qi deficiency and phlegm.3.The TCM syndrome type of Hashimoto's thyroiditis with nodules is related to TSH,FT4,T3 and T4.