Relationship Between Serum Apelin And Ang? And Carotid Intima-media Thickness In Patients With Type 2 Diabetes Mellitus

ObjectiveTo explore the relationship between serum Apelin and Ang?and the thickness of carotid intima-media thickness in type 2 diabetes?T₂DM?.Methods:103 patients with T₂DM were selected in total in this study.All the patients were divided into two groups based on the thickness of CIMT:normal CIMT?CIMT<0.9mm,NCIMT,n=48?and abnormal CIMT?CIMT>0.9mm,ACIMT,n=55?,Healthy Individuals were selected as the normal control group?NC,n=49?.Clinical and biochemical parameters were detected among three groups.Body mass index?BMI?,waist-hip ratio?WHR?,systolic blood pressure?SBP?,diastolic blood pressure?DBP?,fasting glucose?FPG?,HbA1c,total cholesterol?TC?and triglyceride?TG?were measured for all the selected individuals.Besides enzyme-like immunosorbent assay was used to determine fasting serum Apelin and Ang?levels of all the people.and SPSS 24.0 was used for statistical analysis.Results:Compared with the NC group,Serum Apelin levels in the NCIMT group were increased[?2031.88±389.04?vs?2483.43±345.22?pg/ml,P<0.01].The level of Apelin in the NCIMT group was higher than that in the ACIMT group,?2483.43±345.22?vs?2243.98±419.35?pg/ml,P<0.01;Compared with NC group,serum Ang?level was increased in NCIMT group and ACIMT group[?94.56±35.28?vs?112.23±38.31?vs?125.82±35.03?pg/ml,P<0.01].Correlation analysis showed that the serum Apelin was positively correlated with WC,TC,FPG,HbA1c?r=0.223,0.271,0.227,0.580,P<0.05 or P<0.01?;Serum Ang?was positively correlated with HbA1c and TC?r=0.459,0.267,P<0.05 or P<0.01?.Logistic binary regression analysis showed that age?SBP?HbA1c and Ang?were positively correlated with CIMT thickening,while Apelin was negatively correlated to CIMT?P<0.05?.Conclusion:Serum Apelin may be a protective factor for CIMT,while Ang?level may be a risk factor for CIMT,which may be correlated with the development of atherosclerosis in T₂DM.