Correlation Between Vitamin D And C-reactive Protein Interaction And Glucose And Lipid Metabolism In Patients With Depression

Objective: To explore the relationship between vitamin D(Vit D)levels and blood glucose,blood lipid,and C-reactive protein levels in patients with depression,and the relationship between C-reactive protein levels and blood glucose and blood lipid levels.Methods: A questionnaire survey was conducted on 296 patients with depression,including demographic characteristics(age,gender,ethnicity,education level,family income,living environment and working environment,etc.),personal history(nearly one month smoking history,drinking alcohol history,activity,and dietary status in the past week,etc.),family history(with or without mental illness among immediate three generations of relatives),and current medical history(liver,kidney,and other physical disorders,etc.);And physical measurements such as height,weight,waist circumference and blood pressure were measured on site.5m L of fasting venous blood was collected to detect 25-hydroxyvitamin D [25-hydroxyvitamin D,25(OH)D],fasting blood glucose(FBG),total cholesterol(TC),and triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),and hypersensitive C-reactive protein(hs-CRP).All data were input with Epi Data3.1 double and double recording,and the data were analyzed and processed with IBMSPSS 22.0 statistical software.The measurement data of normal distribution are described by mean ± standard deviation(? χ ± S),two groups are compared by independent sample t test,and multiple groups are compared by analysis of variance.Multiple linear regression analysis was used to analyze the relationship between glucose and lipid metabolism indexes and hs-CRP levels and the baseline 25(OH)D level and the relationship between glucose and lipid metabolism indexes and hs-CRP levels.Results: The mean values of 25(OH)D,FBG,TC,TG,HDL-C and hs-CRP in patients with depression were(41.11 ± 11.75)nmol / L,(5.15 ± 0.92)mmol / L,(4.46 ± 1.17))mmol / L,(1.48 ± 1.08)mmol / L,(1.28 ± 0.26)mmol / L,and(1.24 ± 1.51)mmol / L.Vit D was severely deficient in 49 cases(16.6%),Vit D was mildly deficient in 194 cases(65.5%),and Vit D was nondeficient in 53 cases(17.9%).The analysis of variance showed that there were significant differences in FBG,TC,TG,HDL-C and hs-CRP in different Vit D states of depressed patients(P <0.05).The differences between FBG,TC,TG and HDL-C in different C-reactive protein groups were statistically significant(P<0.05).After adjusting for confounding factors,the results of linear regression analysis showed that as Vit D levels increased,FBG(β =-0.018,P <0.001),TC(β =-0.027,P<0.001),and TG(β =-0.007,P = 0.009)and hs-CRP(β =-0.031,P <0.001)gradually decreased,HDL-C(β = 0.005,P = 0.001)gradually increased;Vit D status of depression patients on glucose and lipid metabolism and hs-CRP levels have an effect.With the increase of C-reactive protein levels,the levels of FBG(β = 0.199,P <0.001),TC(β =0.204,P = 0.001),and TG(β = 0.133,P <0.001)gradually increased,and HDL-C(β =-0.072,P <0.001)gradually decreased;different levels of C-reactive protein in depression patients had an effect on glucose and lipid metabolism.The results of analysis of variance showed that there were significant differences in FBG,TC,TG,and HDL-C among different groups when the combined state of Vit D-C-reactive protein in patients with depression(P <0.05).Patients with Vit D deficiency and high hs-CRP had the highest levels of FBG,TC,and TG,and the lowest levels of HDL-C.Conclusion: Vit D and high hs-CRP interact with glucose and lipid metabolism in patients with depression.Vit D deficiency and high hs-CRP patients have the most serious abnormalities of glucose and lipid metabolism,but the causal relationship is not clear.