Analysis Of Clinical Efficacy Of Hyperthermic Intraperitoneal Chemotherapy In Patients With Stage ? And ? Gallbladder Cancer

Objective:To explore the clinical efficacy of hyperthermic intraperitoneal chemotherapy(HIPEC)in the treatment of gallbladder cancer and the factors related to the prognosis of gallbladder cancer,to evaluate the effectiveness of hyperthermic intraperitoneal chemotherapy in gallbladder cancer,and to analyze the clinical application value of hyperthermic intraperitoneal chemotherapy in gallbladder cancer.Cancer treatment provides scientific data.Methods:This study used a retrospective method to collect clinical data of 81 patients with stage III and IV gallbladder cancer who underwent surgical treatment from May 2015 to May 2019 in our hospital,including general information,imaging,and histopathology.And other information,36 cases underwent HIPEC in the surgery + HIPEC group,and 45 cases underwent surgery only in the surgery group.Statistical methods were used to compare the distribution rates and clinical data of different surgical methods in the two groups;survival analysis was compared between the two groups;survival analysis was performed for each single factor in the two groups.Factors with P <0.05 were analyzed by Cox multivariate analysis.Find out the factors that affect the prognosis of gallbladder cancer.Result:There was no statistical difference in the distribution of different surgical methods between the surgery group and the surgery + HIPEC group(P > 0.05).There was no significant difference in clinical data between the surgery group and the surgery + HIPEC group(P> 0.05);the median survival time of the surgery group was 9.800 months,the6-month survival rate was 68.3%,and the 12-month survival rate was32.4%.18 The monthly survival rate was 16.2%.The median survival time of the surgery + HIPEC group was 18.600 months,the 6-month survival rate was 96.9%,the 12-month survival rate was 79.1%,and the18-month survival rate was 45.9%.In univariate analysis,six factors,including treatment mode,tumor stage,tumor diameter,lymph node metastasis,distant metastasis,and vascular invasion,had significant effects on the survival rate of patients(P <0.05);univariate treatment was included in multivariate analysis There were significant correlations between the five indicators of tumor type,tumor stage,tumor diameter,lymph node metastasis,and distant metastasis,and the prognosis of patients(P <0.05).Multivariate analysis results: Surgery + HIPEC are protective factors that affect the prognosis of patients(HR <1),and stage,tumor diameter,lymph node metastasis,and distant metastases are independent risk factors that affect patients' prognosis(HR> 1).Conclusion:1.Surgery combined with hyperthermic intraperitoneal chemotherapy is a protective factor affecting the prognosis of patients with gallbladder cancer.Tumor stage,tumor size,lymph node metastasis,and distant metastasis are independent risk factors that affect the prognosis of patients.2.Hyperthermic intraperitoneal chemotherapy can prolong the survival time of patients with gallbladder cancer.