| ObjectivesProstate cancer(PCa)is the second leading cause of cancer-related deaths in men.Although progress has been made in the treatment of prostate cancer,the prognosis of most patients with prostate cancer is still unsatisfactory.With the deep understanding of tumor inflammation microenvironment,the correlation between inflammation and cancer has become a research hotspot.Many studies have shown that the invasion ability of malignant tumor cells depends not only on the biological behavior of tumor cells,but also on the microenvironment of the tumor,especially the interaction of various inflammatory factors.The inflammatory response plays an important role in tumorigenesis,development and prognosis by stimulating or inhibiting tumor cells.Studies have confirmed that the platelet /lymphocyte ratio(PLR)has become an indicator of the progression and prognosis of many tumors.The purpose of this study was to analyze the correlation between PLR and tumor staging,Gleason score,malignancy,and serum prostate-specific antigen(PSA)in prostate cancer patients,and to explore the clinical significance of PLR in the prognosis of prostate cancer patients.MethodsA retrospective analysis of the first 312 prostate cancer patients diagnosed in the Department of Urology of the Affiliated Hospital of Qingdao University from September2012 to December 2015,of which 98 patients underwent radical prostatectomy and the remaining 214 patients received endocrine therapy or All patients underwent radiotherapy and chemotherapy underwent prostate biopsy under ultrasound guidance.Collect clinical data such as patient age,preoperative serum PSA,preoperative blood routine,preoperative MR examination,bone scan results,puncture pathology,and follow-up,calculate platelet /lymphocyte ratio(PLR),and draw ROC curve to determine the best PLR The cut-off value was 146.9.According to the best cut-off value,prostate cancer patients were divided into high PLR group and low PLR group.The t-test or χ2 test was used to compare the clinical and pathological data between the two groups.Kaplan-Meier method was used to draw the survival curve.The Cox proportional hazard model was used to analyze the relevant factors for univariate and multivariate analysis.All data were analyzed using SPSS 22.0 statistical software.Analysis,p value <0.05 was considered statistically significant.A regular telephone follow-up was performed after treatment.The last follow-up time was December2018.Overall survival(OS)is defined as the time from the date of treatment to death for any reason or the end of the last follow-up.Results1.Prostate cancer patients with elevated PLR tended to have more clinicopathologic characteristics associated with the risk of progression,including advanced age,high Gleason score,high serum PSA level,late TNM stage,high risk,and heavy organ involvement.2.According to Kaplan-Meier survival curve analysis,in terms of overall survival rate(OS),patients in the low PLR group were significantly higher than those in the high PLR group(p<0.05).3.Cox proportional risk model analysis showed that preoperative PLR and Gleason scores were independent risk factors affecting the prognosis of prostate cancer(p = 0.003 and p = 0.023,respectively),while neither age nor serum PSA level were factors affecting the prognosis of prostate cancer.ConclusionsPreoperative PLR has a significant correlation with the malignancy of prostate cancer.In prostate cancer patients,the higher the PLR,the later the clinical stage of prostate cancer,the worse the prognosis.PLR is an independent risk factor for death during the follow-up of prostate cancer patients,and it has important clinical significance for the prognosis of prostate cancer. |
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