Construction Of Indolizine And Imidazo[1,2-a]pyridine Derivatives Through C-H Bond Activation

Compared with the traditional synthesis methods,the functionalization of organic molecules through C-H bond activation has the advantages of atomic economy and step economy.On the other hand,indolizine and imidazo[1,2-a]pyridine are important nitrogen-containing heterocyclic compounds,and their skeleton structures have been found in various drugs,natural products and bioactive molecules.Therefore,it is of great significance to explore the synthesis of indolizine and imidazo[1,2-a]pyridine derivatives.Based on the C-H bond functionalization,two green and efficient synthesis methods were proposed in this paper,and a series of indolizine and imidazo[1,2-a]pyridine derivatives were synthesized.The details are as follows:In the first chapter,the research progress of C-H bond activation reaction in recent years is introduced.In addition,indolizine and imidazo[1,2-a]pyridine derivatives are introduced from application and synthesis.The research content and design idea of this paper are put forward.In the second chapter,we realized the electrocatalysis of C-Se bond formation to synthesize indolizine derivatives.40 products were synthesized from 2-methyl-pyridine,?-bromide and disubstituted-disselenium as reaction substrates.The reaction is oxidized by electrochemistry without other oxidants,mild reaction conditions and wide applicability of reaction substrates,which is of great significance for the enrichment of indolizine compounds.In the third chapter,the selective C-H bond halogenation of imidazo[1,2-a]pyridine without transition metal was realized.A series of 3-Cl or 3-Br substituted imidazo[1,2-a]pyridine derivatives were synthesized.Sodium chlorite and sodium bromate are both halogen sources and oxidants in this reaction,so no other oxidants are added.The reaction has the advantages of simple operation,high selectivity and atomic economy.