Combined Detection Of Serum And Pleural Effusion CRKL And CEA In The Diagnosis Of Malignant Pleural Effusion

Objective:To evaluate the diagnostic value of combined detection of crk-like protein(CRKL)and carcinoembryonic antigen(CEA)in serum and pleural effusion for malignant pleural effusion.Methods:This article collected pleural effusion(PE)from 93 inpatients in the First Affiliated Hospital of Anhui Medical University from October 2017 to March2019.Among them,47 cases were in the Malignant pleural effusion MPE group,including 38 cases of lung adenocarcinoma,6 cases of lung squamous cell carcinoma,and 3 cases of small cell lung cancer.There were 46 patients in the control group,including 35 patients diagnosed with pulmonary infection,5patients with tuberculosis,and 6 other types.The serum and CRKL and CEA levels of 47 patients with malignant pleural effusion and 46 patients with benign pleural effusion were detected by enzyme-linked immunosorbent assay(ELISA).Results:1.There was no significant difference in general information such as gender and age between the two groups of patients(P> 0.05).2.The CRKL and CEA values in serum and pleural effusion of patients with malignant pleural effusion group were higher than those in benign pleural effusion group,and the results had significant statistical differences(P <0.05).3.The results showed that the optimal threshold for CRKL diagnosis of malignant pleural effusion in patients' serum was 2.04 ng / ml,AUC was 0.814,sensitivity was 0.809,and specificity was 0.804.The optimal threshold for CRKL diagnosis of malignant pleural effusion in patients with pleural effusion was3.04 ng / ml,AUC was 0.800,sensitivity was 0.745,and specificity was 0.848.4.The results suggest that the optimal threshold for CEA diagnosis of malignant pleural effusion in patients' serum is 8.4 ng / ml,AUC is 0.837,sensitivity is 0.660,and specificity is 0.913.The optimal threshold for CEA diagnosis of malignant pleural effusion in patients with pleural effusion was 15.29 ng / mlng / ml,AUC was 0.858,sensitivity was 0.745,and specificity was 0.978.5.From the analysis of the ROC curve,it can be found that the AUC value of CRKL in serum and pleural effusion of patients was 0.813,the sensitivity and specificity were 0.809 and 0.804,and the AUC of CEA value in pleural effusion and serum was 0.858.The sensitivity is 0.745 and the specificity is 0.957.The combined detection of CRKL and CEA in patients with pleural effusion showed that the AUC value was 0.961,the sensitivity was 0.894,and the specificity was0.957.The AUC value of the four indicators combined detection was 0.963,the sensitivity was 0.872,and the specificity was 0.978.It can be seen that the combined detection of CRKL and CEA in pleural effusion has the highest sensitivity,and the combined detection of four indicators has the highest AUC value and specificity.Conclusions:1.CRKL in serum and pleural effusion can be used as an important auxiliary indicator to identify benign and malignant diseases.2.The detection of CRKL in serum or pleural effusion combined with CEA,a traditional index of pleural effusion,can improve the accuracy of differential diagnosis of benign and malignant pleural effusion.