Efficacy Of Inhaled Glucocorticoids In Asthmatic Children With Different Body Mass Index

Objective : To analyze and compare the asthma control(c-act score)and lung function improvement of children with different body mass index(BMI)treated by inhaled glucocorticoid,and to explore the efficacy of inhaled glucocorticoid in children with different body mass index(BMI),so as to provide reference for individualized treatment and standardized management of children with asthma.Methods:From August 2018 to October 2019,115 children aged 6 to 11 years old with mild to moderate asthma who were diagnosed and standardized treatment in our hospital were selected.According to body mass index(BMI),13 children were divided into the emaciation group,with an average age of(8.08±1.38).The average age of 37 patients in the normal weight group was(8.76±2.09).The average age of overweight group was(8.97±2.02).The average age of 34 patients in the obesity group was(9.79±2.10).Children in all four groups received standardized treatment according to the 2016 guidelines for the diagnosis and prevention of bronchial asthma in children.Before and after 6 months of treatment,the lung function of the four groups of children was detected,and the asthma control status of the four groups was evaluated with the child asthma control test(c-act)questionnaire.Finally,the four groups of children were compared before and after treatment.Results: There was no significant difference between the four groups in the detection indexes of pulmonary function of children with asthma(P>0.05),showing no statistical significance.After 6 months of treatment,the FVC,FEV1(%),FEF25(%),FEF50(%)and FEF75(%)were significantly improved in the normal weight group(P<0.05).The lung function indexes FEV1(%),FEF50(%)and FEF75(%)in the low weight group were significantly improved(P<0.05).The lung function indexes FVC,FEV1(%)and FEF75(%)of overweight group were significantly improved(P<0.05).Only FVC,FEV1(%)and FEF25(%)were significantly improved in the obesity group(P<0.05).Lung function index FEF75(%)in the normal weight group was significantly better than that in the obesity group,and the difference was statistically significant(P<0.05).There was no significant difference in c-act score in each group before treatment(P>0.05),and the c-act score in the normal weight group was significantly better than that in the super-recombination and obesity group after 6months of treatment,with statistically significant difference(P <0.05).Conclusions:Obesity can affect the lung function and treatment sensitivity of children with asthma.As obesity affects children's lung function and sensitivity to treatment,the importance of individualized treatment for children with asthma is emphasized.