Study On The Relationship Between Adverse Pregnancy History And Cardiovascular Disease In Perimenopausal Women

Objective:To investigate the relationship between the history of adverse pregnancy and perimenopausal women's cardiovascular disease and its clinical significance,and to provide a theoretical basis for the early prevention of cardiovascular disease in women.Methods:A total of 482 perimenopausal women with cardiovascular disease who were treated in the Cardiology Department of the Affiliated Hospital of Chengde Medical College from August 2018 to August 2019 were collected,including 226 cases of coronary heart disease(CHD),256 cases of hypertension,and 314 cases of perimenopausal healthy women who had no cardiovascular disease in the physical examination department of the affiliated hospital of Chengde Medical College were selected as the control group.A questionnaire survey was conducted on the above-mentioned patients to collect data on the pregnancy,parity,age of first childbirth,and complications of pregnancy.Using a case-control study,the hypertension group and the CHD group were compared with the control group.SPSS 20.0 statistical software was used to analyze the data.The measurement data was skewed distribution.The median(lower quartile,upper quartile)was used.[M(P25?P75)] was used for representation.Non-parametric test was used Mann-Whitney U test for analysis;the description of count data is expressed by(n,%),and the ?2test is used as the statistical method.Multivariate unconditional Logistic regression was used to analyze the factors of cardiovascular disease in perimenopausal women.The difference was statistically significant at P <0.05.Results:1.CHD and control group in terms of height,body mass index(BMI),number of miscarriages,history of premature delivery,history of postpartum hemorrhage,history of stillbirth,history of hypertensive disorders of pregnancy(HDP),history of hydatidiform mole,History of ectopic pregnancy,history of neonatal asphyxia,history of fetal malformation,history of premature rupture of membranes,the difference was not statistically significant(P> 0.05);there was a statistical difference between the two groups in gravidity,parity and age of first childbirth Significance(P <0.05).Multivariate logistic regression of CHD showed that the first childbirth age was 20-35 years old and its OR was-0.494(95% CI: 0.254,0.961),which was negatively related to the occurrence of CHD in perimenopausal women.As a protective factor,the age of first childbirth Women between the ages of 20 and35 have a lower risk of CHD during perimenopause.2.There was no significant difference between hypertension and control group in height,number of abortions,history of stillbirth,history of neonatal asphyxia,history of postpartum hemorrhage,history of hydatidiform mole,history of ectopic pregnancy(P> 0.05);There were statistically significant differences in gravidity,Parity,age of first childbirth,history of preterm birth,history of HDP,history of premature rupture of membranes,and BMI(P<0.05).Multivariate logistic regression of hypertension showed that the OR values ??of BMI?28 kg / m2,history of HDP and history of preterm birth were 3.465(95% CI: 2.173,5.526),??3.621(95% CI: 1.080,12.140),2.468(95% CI: 1.073,5.674),all P <0.05,are risk factors for hypertension in perimenopausal women.The first childbirth age between the ages of 20 and 35was-0.468(95% CI: 0.233,0.938),which was negatively related to the risk of perimenopausal hypertension and was a protective factor.The first childbirth age is 20-35 years old.Compared with the first childbirth age?20 years old,women have a lower risk of developing hypertension during perimenopause.Conclusion:1.The results of the coronary heart disease group and the control groupshow that women with a first delivery age between 20-35 years of age have a lower risk of developing coronary heart disease during perimenopause.It is suggested that strengthening reproductive health education for women of childbearing age and avoiding premature and late delivery as much as possible may reduce the risk of coronary heart disease in women in the long run.2.The results of the hypertension group and the control group showed that HDP history,premature birth history,and BMI?28kg / m2 were all independent risk factors for hypertension in perimenopausal women.Studies have shown that women between the ages of 20 and 35 during the first childbirth have a lower risk of developing high blood pressure during perimenopause.It is suggested that educating women of childbearing age,pregnant at the right age,and paying attention to pregnancy inspection after pregnancy to prevent the occurrence of preterm birth or HDP may reduce the risk of long-term hypertension.For women of childbearing age who have a first childbirth age of <20 or?35 years of age,who have had premature birth or HDP,they should strengthen health education,adhere to a healthy lifestyle,control their weight,and perform regular birth tests,which may reduce their perimenopausal cardiovascular disease risks of.