The Role Of Leptin And Its Receptor In The Formation Of Cholesterol Gallstones

Objective: in this study,the serum leptin,bile leptin,OB-R,JAK,blood lipid,lipoprotein and some apolipoproteins in patients with gallstone were measured,and the potential relationship between them was discussed Function.Methods: a total of 100 cases of laparoscopic cholecystectomy in our department were randomly selected,The patients were divided into two groups according to the criteria of inclusion,i.e.cholesterol gallstone group(50 cases)and polyp group(50 cases).The general situation,serum leptin content,bile leptin content,OB-R content of gallbladder wall,JAK content of gallbladder wall,serum total cholesterol(TC),serum total bile acid(TBA),triglyceride(TG),high-density lipoprotein(HDL),low-density lipoprotein(LDL)of the two groups were analyzed LDL,LP,apo-AI and apo-B were detected and the results were analyzed statistically.Results: compared with the polyp group,the serum leptin content,bile leptin content,OB-R expression level,JAK expression level,lipids and lipoproteins in the gallstone group were significantly higher(P < 0.05),while the serum HDL and apo AI were significantly lower(P < 0.05),and the expression level of OB-R in the gallstone group was positively correlated with most other indexes(P < 0.05),only the indexes of HDL,apo AI and bile TBA were found Negative correlation(P < 0.05).Conclusion:1.The high expression of serum leptin,bile leptin,OB-R in gallbladder wall and JAK in gallbladder wall is likely to affect blood lipid,lipoprotein,apolipoprotein and bile lipid to eventually lead to the formation of cholesterol gallstone.The increase of leptin content in bile and OB-R expression in gallbladder wall may be the direct cause of cholesterol gallstoneformation.2.The expression of serum leptin,bile leptin,OB-R in gallbladder wall and JAK in gallbladder wall were significantly increased in cholelithiasis patients,and the expression of OB-R in gallbladder wall was positively correlated with other three items.3.There are many metabolic factors in the patients with cholesterol gallstones.