| Objective:Enlarged facial pores is not a medical disease,but it is one of the important factors that affect the appearance of facial skin.In previous clinical studies,both the1565 nm non-ablative fractional laser and the long-pulsed 1064 nm neodymium:yttrium-aluminum-garnet(Nd:YAG)laser have shown certain effects in treating enlarged facial pores.This article aims to evaluate and compare the safety and efficacy of two lasers in the treatment of enlarged facial pores.Method:In this study,we recruited 27 subjects with enlarged facial pores to participate in the trial.All subjects were treated with a 1565 nm laser on the left face with an energy range of 34-40 m J and a density of 250-300 ub/cm~2.All subjects were treated with a long-pulsed 1064 nm laser on the right face with a spot size of 10 mm,an energy density range of 45-50 J/cm~2,a pulse time of 50 ms,and a repeat frequency of 2 Hz.A total of 5 treatments were performed,and the interval between the two treatments was 2 weeks.Two months after the end of the 5 treatments,the subjects were followed up again.The subjects'pain and burning sensation were recorded and scored at each treatment.After each treatment,the subjects scored the degree of pore improvement,and the satisfaction of pore improvement was evaluated during follow-up.Before and after treatment and during follow-up,facial photos were taken with VISIA facial skin imaging analyzer to record changes in the number of facial pores.During the study period,all adverse reactions,including erythema,edema,and pigmentation,et al,were recorded.Result analysis:The efficacy of two laser treatments was evaluated by comparing the pore counts before and after treatment and the subjective evaluation of the subjects.The safety of the two lasers was evaluated by comparing the adverse reactions such as pain,burning sensation and erythema.Result:Of the 27 subjects,a total of 18 completed all follow-ups and were included in the final statistics.The average number of pores before treatment on the 1565 nm laser treated side of the 18 subjects was 1191±469.5.And the average number of pores after 5 treatments was 848.8±363.6,the average percentage reduction of pores was29.5%.The number of pores evaluated after 5 treatments was significantly reduced compared with before treatment(p<0.000).The average number of pores at follow-up 2 months after the treatment was 852.1±372.5,and the average percentage reduction in pore volume at follow-up was 29%.The number of pores evaluated at follow-up was also significantly reduced than before treatment(p<0.000).After each treatment,the average scores of pore improvement were 0.67±0.49,0.89±0.32,1.39±0.5,1.61±0.5,2.06±0.87.At the follow-up,the average satisfaction score of all participants was3.83±0.92.The average number of pores before treatment on the 1064 nm laser treated side of the 18 subjects was 1183.3±520,And the average number of pores after 5treatments was 919.8±394.5,the average percentage reduction of pores was 22%.The number of pores evaluated after 5 treatments was significantly reduced compared with before treatment(p<0.000).The average number of pores at follow-up 2 months after the treatment was 920.5±392.7,and the average percentage reduction in pore volume at follow-up was 21.7%.The number of pores evaluated at follow-up was also significantly reduced than before treatment(p<0.000).After each treatment,the average scores of pore improvement were 0.5±0.51,0.72±0.46,1.28±0.46,1.44±0.51,1.89±0.76.At follow-up,the average satisfaction score of all participants was3.61±0.92.After 5 treatments and follow-up,there was no statistically significant difference in the mean pore reduction between the two lasers.After 5 treatments,the score of pore improvement was higher on the 1565 nm laser treated side than on the 1064 nm laser treated side(p<0.000).At the follow-up,subjects'satisfaction score for pore improvement was also higher at the 1565 nm laser treated side than at the 1064 nm laser treated side(p<0.000).The average pain score at 1565 nm laser treated side was 4.39±1.24,and the average burning sensation score was 1.61±0.85.Short-term adverse reactions after treatment included erythema,edema,and crusting,and one subject had pigmentation.The average pain score at 1064 nm laser treated side was 2.78±1.9,and the average burning sensation score was 0.83±0.92.Short-term adverse reaction after treatment was erythema,and no long-term adverse reactions were seen.Conclusion:The 1565 nm non-ablative laser and the long-pulsed 1064 nm Nd:YAG laser have exact treatment effect on facial pores,and the former is slightly better than the latter.Both lasers are safe. |
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