Relationship Between Vaginal Microecology And High-risk Human Papillomavirus Infection

Part One Correlation analysis between vaginal microecological abnormalities and high-risk human papillomavirus infectionObjective: Study the correlation between vaginal microecological abnormalities and high risk-human pappilomavirus(HR-HPV)infection.Methods: Retrospective analysis was performed on the clinical data of 18-48 years old women who received HR-HPV tests(using Aptima HPV and Aptima HPV-GT tests)and vaginal microecological tests(using the quintuplet enzyme method)at the gynecological outpatient department of Hebei Provincial People’s Hospital from August to December 2019.In order to study the correlation between vaginal microecological abnormalities and HR-HPV infection,the study subjects were divided into normal vaginal microecological groups and abnormal groups,and the HR-HPV infection rates of the two groups were analyzed.Results:1.General information: A total of 2537 clinical data were collected in this study,with an average age of 35.26 ± 7.17 years and a median age of 34.0 years(30.0～41.0 years),including 497 normal vaginal microecology and 2040 abnormal vaginal microecology.2.Comparison of HR-HPV infection rates in different groups of vaginal microecology: There were 47 cases of HR-HPV infection in the normal vaginal microecology group(9.50%)and 751 cases of HR-HPV infection in the abnormal vaginal microecology group(36.80%).The HR-HPV infection rate in the vaginal microecological abnormality group was higher than the HR-HPV infection rate in the normal vaginal microecological group,and the difference was statistically significant(P < 0.05).Conclusion: There is a correlation between vaginal microecology and HR-HPV infection.Patients with abnormal vaginal microecology are more likely to be infected with HR-HPV.Part Two Correlation analysis of BV,VVC,TV and high-risk human papillomavirus infectionObjective: Study the relationship between bacterial vaginosis(BV),vulvovaginal candidiasis(VVC),trichomonas vaginitis(TV)and HR-HPV infection.Methods: From August to December 2019,female patients aged 18-48 years who were treated in the department of gynecology of Hebei Provincial People’s Hospital and underwent HR-HPV detection(Aptima HPV and Aptima HPV-GT detection)and vaginal microecological detection(quintuplet enzyme method)were selected as the study subjects.In order to study the correlation between BV,VVC,TV and HR-HPV infection,subjects were divided into HR-HPV negative group and HR-HPV positive group,and the detection rates of BV,VVC and TV in the two groups were analyzed and the influencing factors of HR-HPV infection were analyzed by multivariate logistic regression.Results:1.General information: A total of 2537 subjects were included in this study,with an average age of 35.26±7.17 years and a median age of 34.0 years old(30.0～41.0 years),among which 1739 cases were HR-HPV negative and 798 HR-HPV positive.2.Comparison of BV,VVC and TV detection rates in different groups of HR-HPV: The detection rates of BV,VVC and TV in HR-HPV negative groups were 9.4%(163/1739),9.1%(158/1739),1.3 %(23/1739).The detection rates of BV,VVC and TV in the HR-HPV positive group were 13.8%(110/798),11.9%(95/798),and 2.6%(21/798).The detection rates of BV,VVC and TV in the HR-HPV positive group were higher than those in the HR-HPV negative group,and the differences were statistically significant(P < 0.05).3.Multivariate logistic regression analysis of HR-HPV infection: Patients with BV,VVC and TV were 1.646 times,1.466 times and 2.227 times more likely to be infected with HR-HPV than other patients,respectively(P < 0.05),OR values and 95% CI were 1.646(1.268～2.136),1.466(1.117～1.926),2.227(1.223～4.055).Conclusion: There is a certain correlation between BV,VVC,TV and HR-HPV infection,which is a risk factor for HR-HPV infection.