The Effect Of Methylamphetamine Addiction On The Attention Processing Before Auditory Stimulation And Related Intervention Study

Objectives To explore the effect of methamphetamine addiction on pre-attention processing and the effectiveness of intervention after repeated transcranial magnetic stimulation using ERP technology,and to provide a new intervention method to restore the cognitive impairment caused by methamphetamine addiction.Methods The study was divided into two experiments.In the first experiment,20 methamphetamine detoxifiers from a compulsory isolation detoxification center in Hebei were selected as the methamphetamine addiction group,and 19 normal subjects whose age,smoking level and education level matched were selected as the control group,using Guangzhou Runjie WJ-The type 1A medical event-related potentiometer recorded the MMNof the two groups of subjects,and used EEGLAB software platform for conversion analysis to compare the differences in MMN latency and amplitude between the two groups.In the second experiment,40 methamphetamine detoxifiers of the drug addiction treatment center were randomly divided into methamphetamine addiction intervention group and methamphetamine addiction control group.Repeated transcranial magnetic stimulation was used to intervene in the addiction intervention group,and the same intervention scheme was used to perform pseudo-stimulation intervention in the addiction control group.The differences in MMN latency and amplitude before and after intervention were compared between the two groups.Results 1.Experiment 1 found that both the addiction group and the control group could detect the MMN on the F3,Fz and F4 electrode points,and the MMN waveform of the methamphetamine addiction group was not regular.The MMN amplitudes of the three electrode points in the addiction group and the control group were significantly different(P<0.05),and there was no difference in the incubation period(Ps>0.05).2.The results of Experiment 2 found that before repeated transcranial magnetic stimulation intervention,there was no difference in the MMN amplitude and latency of the three electrode points in the two groups(Ps>0.05).After the intervention,the MMN amplitudes of Fz and F4 in the two groups were significantly different(Ps<0.01),and the MMN amplitudes of F3 were not significantly different(P>0.05);there was no difference in the MMN latency of the three electrode points in the two groups(Ps>0.05).The comparison between the addiction intervention group and the addiction control group before and after the intervention found that the MMN latency of the three electrode points in the intervention group was significantly different(Ps<0.05);the amplitude of the MMN of Fz and F4 was significantly different(Ps<0.05),and The amplitude of the MMN of F3 difference is not significant(P>0.05).After r TMS intervention,the MMN latency and amplitude of F3,Fz,and F4 in the control group were not significantly different(Ps>0.05).Conclusions 1.Meteor addiction pays attention to the automatic processing process before it is affected,which impairs the cognitive function.2 After repeated transcranial magnetic stimulation interventions,the cognitive function and pre-attention processing ability of the addiction intervention group have improved,and the r TMS scheme of bilateral simultaneous stimulation is effective.Figure14;Table16;Reference 107...