| Objectives To retrospectively analyze the clinical case data of 60 epilepsy children and 30 healthy children in outpatient and inpatient treatment of Hebei Provincial People's Hospital in the past two years,and to understand levetiracetam(LEV)and sodium valproate(VPA)changes of liver and kidney function indexes before and after treatment,and explore the related mechanisms that cause the changes,provide a clinical reference for the rational and safe application of antiepilepsy drugs(AEDs)in children with epilepsy.Methods A total of 60 children with epilepsy who were treated in outpatient and inpatient hospitals of Hebei Provincial People's Hospital from October 2017 to October 2019 were randomly selected as the case group and divided into separate oral levetiracetam groups(30 cases)according to different treatment methods.Oral sodium valproate group(30 cases).At the same time,30 children randomly selected from the children's health clinic during the same period were selected as the control group.SPSS 21.0 statistical software was used to analyze the data and compare and analyze the changes of liver and kidney function indexes of each drug group before and after administration,and compared with the normal control group.Results 1 Age and gender: The average age of children in the healthy control group was(6.80±3.57)years,the average age of the children in the levetiracetam group was(7.63±4.38)years,and the average age of the children in the sodium valproate group was(6.05±3.00)years,and there is no statistical significance in age(P>0.05).The proportions of boys and girls in the healthy control group were 53.3% and 46.7% respectively,the proportions of boys and girls in the levopiracetam group were 56.7% and 43.3%,and the proportions of boys and girls in the sodium valproate group were 70% and 30% respectively.There was no statistical significance in gender comparison(P> 0.05).2 Comparison of time taken by each drug group: the average time taken by the levetiracetam group is(1.84±1.08)years,and the average time taken by the sodium valproate group is(2.11±1.16)years.No statistical significance(P>0.05).3 Comparison of renal function before and after taking medicine in each medicine group: serum uric acid level in each medicine group after taking AEDs for at least half a year was higher than before taking medicine,the difference was statistically significant(all P<0.05).There was no statistically significant difference in urea and creatinine levels before and after administration in each drug group(all P>0.05).4 Comparison of liver function before and after medication in each drug group: There was no significant difference in liver function level before and after medication in all drug groups(all P>0.05).The average level of Alanine aminotransferase ALT in the levetiracetam group was(14.29±3.49)U/L before taking the drug,and the average level after taking the drug was(13.01±2.66)U/L,the difference was not statistically significant(P>0.05).The average level of aspartic transaminase AST before taking the drug was(31.68±8.19)U/L,and the average level after taking the drug was(29.56±10.41)U/L,the difference was not statistically significant(P>0.05).The average level of ALT in the sodium valproate group was(15.03±4.01)U/L before taking the drug,and the average level after taking the drug was(14.69±5.09)U / L.There was no statistically significant difference before and after taking the drug(P>0.05).The average level of AST before taking the drug was(28.92±10.59)U/L,and the average level after taking the drug was(29.43±9.59)U/L.The difference was not statistically significant(P>0.05).5 Comparison of renal function between each drug group and normal control group: The levels of various renal function indicators of each drug group were compared with the normal control group for at least 6 months.It was statistically significant(all P<0.05).Serum urea and creatinine levels were not statistically significant compared with the normal control group(all P>0.05).The average level of uric acid in the healthy control group was(225.87±46.01)umol/L,the average level of uric acid in the levetiracetam group was(349.31±102.91)umol/L,and the average level of uric acid in the sodium valproate group was(340.30±97.05)umol/L,compared with the healthy control group,the differences were statistically significant(all P<0.05).6 Comparison of liver function between each drug group and normal control group: the levels of liver function indexes in each drug group for at least 6 months were not statistically significant compared with healthy normal control group(all P> 0.05).7 The medication time of each drug group is different,and the comparison of serum uric acid level: the uric acid levels of the two drug groups before the medication,1 year of medication and 1.5 years of medication are compared,the difference is statistically significant(P<0.05).Among them,the comparison showed that the difference between the 1 year and 1.5 years of the drug was statistically significant compared with that before the drug(all P<0.05),and the difference between the 1.5 year of the drug and the 1 year of the drug was not statistically significant(P>0.05).Conclusions 1 The results of this study showed that after VPA or LEV treatment was compared with pre-treatment and control groups,there was no significant difference in liver function indexes and creatinine and urea in renal function,and the level of uric acid in renal function increased,while medication the length of time has little effect on changes in uric acid levels.This suggests that VPA and LEV will lead to an increase in serum uric acid levels,but the application of reasonable doses of AEDs will not continue to increase with the prolonged treatment time.It is suggested that these two drugs may have potential nephrotoxicity.During the application of these two AEDs,the serum uric acid level should be monitored regularly.2 Studies have shown that uric acid is related to oxidative stress in the body.In this study,the serum uric acid level after treatment with VPA and LEV is higher than before the drug is used.To increase the relevant,specific related mechanisms need further in-depth study and discussion.Figure[0];Table[7];Reference 125... |
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