Clinical Analysis Of 100 Cases Of Nonalcoholic Fatty Liver Disease

Objective: Our aim was to analyze the prevalence and clinical characteristics of nonalcoholic fatty liver disease(NAFLD)in those outpatients,and to explore the differences of nonalcoholic fatty liver disease under different age,sex and risk stratification,so as to provide clinical reference for the prevention and treatment of nonalcoholic fatty liver disease.Methods:The study was recruited 100 patients with NAFLD who were newly diagnosed and 100 healthy people as control group who had no abnormality in physical examination respectively in the outpatient department of digestive medicine,outpatient department of endocrinology and physical examination center from June 2019 to October 2019.First,we developed an unified questionnaire,containing the general information of those cases such as the patient’s name,sex,age,eating habits,drinking,exercise,past medical history,etc.Then we measured the body mass index(BMI),and collected the fasting venous blood,so as to measure the fasting blood glucose(FBG),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)of each case.Additionally,we calculated the index of insulin resistance homa model(Homal R)as follows: HOMA-IR=FPG×FINS/22.5;HOMA-β=20×FINS/(FPG-3.5).Finally,the general data of the two groups were compared by the age distribution of NAFLD group,laboratory indicators(BMI,FBG,TC,TG,LDL-C,HDL-C),characteristics of metabolic syndrome(MS)in the NAFLD group,and characteristics of insulin cell function in both two groups.Results:1.Among the 100 patients with nonalcoholic fatty liver disease,there were 63 males and 37 females,aged from 20 to 75 years old,with an average age of 57.43±5.49 years.The detection rate of male in the 60-year-old age group and the detection rate of female in the 50-year-old age group was higher than other groups.Among them,19 cases of male in the 60-year-old age group with a detection rate of 19.00% and 11 cases of female in the 50-year-old age group with a detection rate of 11.00% were detected.In terms of trend,the detection rate of NAFLD increased gradually before the age of 70 in males and before the age of 50 in females.2.The mean value of BMI in patients with nonalcoholic fatty liver disease was higher than that in control groups,which was statistically different(BMI: 27.56±2.71 kg/m2 vs 24.33±2.75 kg/m2)(P<0.05).FBG,TC,TG,LDL-C in patients with nonalcoholic fatty liver disease were significantly higher than those in control groups(FBG: 6.15±0.27 mmol/L vs 5.43±0.28 mmol/L;TC:5.37±0.17 mmol/L vs 4.74±0.15 mmol/L;TG: 3.49±0.19 mmol/L vs 1.78±0.54 mmol/L;LDL-C: 2.86±0.72 mmol/L vs 2.67±0.62 mmol/L)(P<0.05).HDL-C in patients with nonalcoholic fatty liver disease were significantly lower than those in control groups,which was statistically different(HDL-C: 1.26±0.29 mmol/L vs 1.39±0.30 mmol/L)(P<0.05).3.Among the 100 cases with nonalcoholic fatty liver disease,31 cases with the proportion of 31.00% had two metabolic syndromes,mainly in overweight or obese with hypertension.There were 38 cases with the proportion of 38.00% had three metabolic syndromes,mainly in overweight or obese accompanied with hypertension and hyperglycemia,and 22 cases with the proportion of 22.00% had four metabolic syndromes,containing overweight or obese,hypertension,hyperglycemia,high TG level and low HDL-C level.There were 9 cases without any metabolic abnormality,which accounted for 9.00% of the whole nonalcoholic fatty liver cases.4.In the NAFLD group,there were 56 cases with mild fatty liver changes,25 cases with moderate fatty liver changes,and 19 cases with severe fatty liver changes,which were accounted for 56.00%,25.00% and 19.00% respectively.Higher FINS and lower Homa-value was found in the NAFLD group than those in the control group,and the difference was statistically significant(P < 0.05).The difference of Homal R between two groups were statistically significant(P < 0.05).Conclusions:1.Nonalcoholic fatty liver disease is a risk age for men aged 60 and older and women aged 50 and older,and is higher in men than in women.2.Nonalcoholic fatty liver disease is mainly characterized by overweight or obesity,hyperglycemia,hypertension,etc.and with the aggravation of fatty liver.3.The degree of fatty change in liver was correlated with insulin resistance and decreased islet insulin cell function in patients with nonalcoholic fatty liver disease.4.Nonalcoholic fatty liver disease is associated with metabolic factors.