Comparison Of Clinical Characteristics And Pulmonary Function Of ACO And COPD Patients

Objective: To compare the clinical characteristics and pulmonary function of patients with ACO and COPD,and to study the disease characteristics of ACO,provide reference for differential diagnosis of ACO.Methods: A retrospective analysis of a total of 88 cases of patients in the outpatient service of respiratory department two of the Second Affiliated Hospital of Hebei Medical University from November 2018 to January 2020.The basic information of patients and CAT score was obtained by questionnaire,and to complete the FENO tests,bronchial provocation tests or bronchial dilation tests and pulmonary function tests.According to the diagnostic recommendations in Ges EPOC2017 and the examination results,the enrolled patients were divided into ACO group(34 cases,38.64%),COPD group(19 cases,21.59%)and control group(35 cases,39.77%).Record and compare the relevant data.Results: The gender difference between the three groups is statistically significant(P<0.05).The proportion of female patients in the ACO group is larger than that of male patients,while the proportion of male patients in the COPD group is larger than that of female patients.There is a statistically significant difference in smoking history between the three groups(P<0.05),and the proportion of smokers in the ACO group is significantly lower than that in the COPD group.There is no significant difference in smoking index between ACO group,COPD group and the control group(P>0.05).Smoking index of COPD group was significantly higher than that of the control group,and the difference is statistically significant(P<0.05).BMI of ACO group was lower than that of the control group,and the difference is statistically significant(P<0.05).There was no significant difference in BMI between ACO group and COPD group(P>0.05).The age of patients in ACO group and COPD group is higher than that in the control group,and the difference is statistically significant(P<0.05).There is no significant difference in age between ACO group and COPD group(P>0.05).ACO group FENO is significantly higher than COPD group and the control group,and the difference is statistically significant(P<0.05).There is no significant difference in FENO between COPD group and the control group(P>0.05).FEV1% of the ACO group and COPD group is significantly lower than that of the control group,with statistically significant difference(P<0.05),while FEV1% of the ACO group and COPD group has no statistically significant difference(P>0.05).FEV1/FVC% in ACO group and COPD group was lower than that in the control group,and the difference is statistically significant(P<0.05).There is no significant difference in FEV1/FVC% between ACO group and COPD group(P>0.05).CAT scores of ACO group and COPD group are higher than those of the control group,and the difference is statistically significant(P<0.05).CAT score of ACO group is significantly higher than that of COPD group,and the difference is statistically significant(P<0.05).CAT scores of ACO group and COPD group are significant negatively correlated with FEV1%(r=-0.898,P<0.01),(r=-0.808,P<0.01),while CAT scores of control group are not correlated with FEV1%(r=0.099,P=0.571).Conclusion:Compared with COPD patients,the proportion of female is higher and the proportion of smokers is lower in ACO patients;ACO patients are in worse health,the CAT scores are helpful for ACO screening;FENO can be used to differentiate the diagnosis of ACO,Clinicians can decide whether to use ICS treatment based on the patient's FENO level,so as to control symptoms and improve prognosis.