Correlation Between Serum Ferritin And Postmenopausal Osteoporosis

Objective: To explore the effect of serum ferritin on bone metabolism in patients with postmenopausal osteoporosis.Methods:183 cases of postmenopausal women who diagnosed as osteoporosis by DXA from May 2018 to December 2019 at The Third hospital of Hebei medical university were enrolled as osteoporosis(OP)group,and 98 cases of postmenopausal women with normal bone mineral density(BMD)as control group.Clinical and biochemical characteristics were collected.Compare of the difference between the two groups.Correlation between serum ferritin with clinical parameters and bone mineral density was performed.Results: 1.General indicators between the two groups: Compared with control group,the age of OP patients was significantly older [(67.67±8.78)years VS(58.86±7.90)years],while the age of menopause was relatively younger [(48.83±3.61)years VS(49.99±2.30)years],contributing to longer menopause period[(18.73±9.75)years VS(8.14±7.88)years](P all<0.05).There was no significant difference in BMI between the two groups(P>0.05).2.Biochemical indexes and bone mineral density were compared between the two groups: TC[(4.92±1.1)mmol/L VS(4.48±1.17)mmol/L)] was statistically higher in OP group than that in control group(P<0.05),while the bone density of lumbar vertebrae [(0.762±0.123)g/cm2 VS(1.063±0.088)g/cm~2] and femoral neck [(0.709±0.12)g/cm2 VS(0.989±0.67)g/cm~2] was lower in OP group as compared to those in control group(P<0.05).There were no significant difference in ALT,AST,CRP,TG,HDL-C,LDL-C,FBG,Cr,UA,serum calcium,serum phosphorus and ALP between the two groups(P>0.05).3.Serum ferritin between the two groups: Serum ferritin [(177.5±85.11)ug/L VS(104.29±43.64)ug/L] was statistically higher in OP group than that in control group(P<0.05).4.Correlation between serum ferritin with clinical indicators and bone mineral density: Serum ferritin level was positively correlated with BMI(r=0.188,P<0.05)and FPG(r=0.153,P<0.05),while negatively correlated with lumbar vertebral(r=-0.231,P<0.05)and femoral neck bone density(r=-0.257,P <0.05).5.Serum ferritin and age: Serum ferritin was increased with age.Conclusions:1.Iron accumulation exists in postmenopausal women with osteoporosis.2.Elevated serum ferritin may be a risk factor for bone mineral density loss in patients with postmenopausal osteoporosis.3.It is unclear whether dyslipidemia is a risk factor for postmenopausal osteoporosis.