Correlation Analysis Of Iron Accumulation,Bone Turnover Marker And Bone Mineral Density In 376 Cases Of Postmenopausal Hip Fracture Patients

Objective To explored the correlation between the indexes of iron accumulation, bone turnover and bone mineral density by retrospective analyzing the clinical data of patients with hip fracture in postmenopausal women, and in order to further explore the role and significance of iron accumulation in postmenopausal hip fracture.Method A total of 376 cases of postmenopausal women with hip fragility fractures aged from 55 to 94 years old,with an average age of 74.1±9.6 years,from June 2010 to December 2014 were collected. Patients were divided into 3 groups according to the value of T of the bone mineral density(BMD).And each group’s body mass index,the blood routine index,blood biochemical index,bone turnover markers and iron metabolism index were statistically analyzed.Result(1)Among these 3 groups,the group with lower BMD was resulted in higher serum ferritin(SF);(2)Age, body mass index, serum ferritin, hemoglobin, C reactive protein and transferrin were the factors that affect the BMD.With the control of age and body mass index,such factors, serum ferritin and bone mineral density were significantly negatively correlated(Femoral neck r=-0.446,P<0.01;Lumber r=-0.349,P<0.01);(3)Serum ferritin was positively correlated with β-CTx(r=0.166,P<0.01), whereas it was not associated with P1 NP.Conclusion Patients with hip fracture in postmenopausal women,bone mineral density decreased significantly with the increase of serum ferritin while increased serum ferritin may be an independent risk factor for the lower bone mineral density;Serum ferritin was also associated with the increase of osteoclasts activity.