| Objective:Lymphocyte monocyte ratio(LMR)has been considered as a prognostic factor in patients with lymphoma,which focused on diffuse large B-cell lymphoma(DLBCL)and Hodgkin lymphoma(HL).Recently,many relevant clinical studies have been published,and the results were inconsistent.To gain a more comprehensive view of the prognostic value of LMR,we conducted a meta-analysis on the significance of peripheral LMR in all types of lymphoma.Methods:Pub Med,Web of Science,Embase and Cochrane Library were searched for relevant articles,while Newcastle-Ottawa Scale was used to evaluate the quality of adopted articles.Hazard ratio(HR)and its 95% confidence interval(CI)of OS and PFS were extracted and pooled on stata12.1.Results:Forty studies were eligible and a total of 10446 patients were included.Low LMR was associated with a poor OS(HR=2.45,95%CI=1.95-3.08)and PFS(HR=2.36,95%CI=1.94-2.88).In the analysis of lymphoma subtypes,similar results were seen inHL,NHL and its subtypes including DLBCL,NK/T cell lymphoma,and follicular lymphoma.In addition,low LMR was related with higher LDH(OR=2.26,95%CI=1.66-3.09),tumor staging(OR=0.41,95%CI=0.36-0.46),IPI score(OR=0.40,95%CI=0.33-0.48),but not with bone marrow involvement(OR=1.24,95%CI=0.85-1.81)or pathological type(OR=0.69,95%CI=0.41-1.16).Conclusion:Low LMR in peripheral blood indicates poor prognosis in patients with lymphoma.As a simple clinical indicator,peripheral blood LMR combined with existing prognostic factors can improve the accuracy of lymphoma prognosis assessment. |
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