The Relationship Between AVS And Severity Of Coronary Artery Disease In Patients With Acute Coronary Syndrome

Objective: To investigate the relationship between aortic valve sclerosis(AVS)and the severity of coronary artery disease in patients with acute coronary syndrome.Methods: 1.A total of 367 patients with acute coronary syndrome who were admitted to the first hospital of hebei medical university from January 2018 to March 2019,were admitted to complete the examination by Echocardiography and coronary angiography.The general conditions of patients were recorded.According to the result of Echocardiography,the patients were divided into NAVS group,AVS 1 group and AVS 3 group.Basic clinical data and coronary artery lesion counts,the Gensini score comparison as well as the risk factors of patients(age,gender,smoking,diabetes,hypertension,dyslipidemia,allergic C-reactive protein levels,centriole and lymphocyte ratio,lipoprotein a and AVS)in three groups between coronary artery lesion degree were on correlation analysis.2.SPSS 26.0 data software was used for statistical analysis of the data.Kolmogorov-smirnov tested whether the measurement data conforms to normal distribution or approximate normal distribution,and Levene tested homogeneity of variance,which conforms to normal distribution and has homogeneous variance.Anova was applied,that is,if the difference is statistically significant,the student-news-keuls method was applied for pair-wise comparison.Non-parametric rank-sum test or mann-whitney U test,i.e.,quartile spacing M(Q1,Q3)or percentage,was used for variance inequality,and Kruskal Wallis H test was used for pantwise comparison.In this study,all theoretical frequencies in each group were ?5,and the X2 test was used for inter-group comparison.Spearman or Pearson was used to analyze the correlation between the risk factors of severe coronary lesion in patients with acute coronary syndrome.Risk factors for severe coronary lesions in patients with acute coronary syndrome were analyzed using an ordered Logstic regression.Test standard =0.05.Results: 1.A total of 367 patients with ACS were included in the study,which were divided into the NAVS group(182 cases),AVS1 group(65 cases)and AVS3 group(120 cases)according to AVS diagnosis and score criteria.After the differences in age,diabetes,lipoprotein a level,c-reactive protein level and other aspects of the three groups were statistically significant(P< 0.05),AVS 3 group was higher in age and the level of lipoprotein a compared by AVS 1 group.The prevalence of diabetes in AVS group was higher than that in NAVS group,but there was no significant difference between AVS 1 group and AVS3 group.There were no significant differences among the three groups in gender,body mass index(BMI),smoking,hypertension,dyslipidemia and NLR(P>0.05).2.There was a statistically significant difference in the number of vessels in coronary artery lesions in the three groups(P=0.005).There was no statistically significant difference between the NAVS group and AVS 1 group(P=0.192),while there was a statistically significant difference in the number of lesion vessels between the NAVS group and AVS3 group(P=0.001).There was a statistically significant difference among the three groups in terms.There was no statistically significant difference of Gensini score between the NAVS group and AVS 1 group(P=0.192),while there was a statistically significant difference between the NAVS group and AVS 3 group(P=0.001).3.AVS(r=0.269,P<0.001),age(r=0.131,P=0.012),diabetes(r=0.152,P=0.004),and CRP levels(r=0.120,P=0.04)were positively correlated with Gensini score,while the women ratio(r=-0.178,P < 0.05)were negatively correlated with Gensini score.Ordered logistic regression analysis determined the independent correlation between age,gender,AVS and Gensini score in patients with acute coronary syndrome(r=2.32,r=0.46,r=1.75,all P?0.05).Conclusion: AVS was independently correlated with coronary angiography Gensini score in patients with acute coronary syndrome,and high AVS score predicted the complexity and severity of coronary artery disease to a certain extent.