Ratio Of Apolipoprotein B/Low Density Lipoprotein:A Clinical Indicator For Vascular Cognitive Impairment

Objective To investigat.e the correlation between vascular cognitive impairment and apolipoprotein B/low density lipoprotein(apoB/LDL).Methods From September 2016 to March 2018,patients with cerebral infarction were selected from the department of neurology of the Handan First Hospital,we collect the basic clinical data of the patients,include gender,age,height,body mass index(BMI),education,hypertension,hyperlipidemia and heart history.The mini-mental state scale(MMSE)and Montreal cognitive assessment scale(MoCA)was evaluated within 4 days after the onset of the disease.According to the score,the patients were divided into simple infarct group(n=57)and cognitive impairment group(n=71).The latter were divided into mild vascular cognitive impairment group(n=36)and vascular dementia group(n=35)according to the degree of cognitive impairment The frequency of sex,smoking,drinking and hyperlipidemia were compared between mild vascular dementia group(n=28)and moderate vascular dementia group(n=27).T test and linear regression were used to analyze the results.Results This study included 128 patients with acute cerebral infarction,including 57 patients with simple infarction and 71 patients with cognitive impairment The results were as follows:there was no significant difference in sex,age,hypertension,smoking history between patients with simple infarction and cognitive impairment(p>0.05),and there was no significant difference in blood lipid subtypes between the two groups(p>0.05),However,we found that the ratio of serum apoB/LDL was positively correlated with MMSE score(R2=0.061,P=0.005,DW=0.999)and MoCA score(R2=0.056,P=0.007,DW=1.077).There was a significant difference in serum apoB/LDL between patients with simple infarction and cognitive impairment(p=0.005),but there was no significant difference between patients with different degrees of cognitive impairment(p<=0.051).Conclusion The conclusion of this case-contel study shows that serum apoB/LDL ratio can predict VCI in patients with cerebral infarction.