Acute Aerobic Exercise Ameliorates Inhibitory Control And Its Neurological Mechanisms In Methamphetamine-Dependent Individuals

Objective: this study was to explore the effect of one-off acute moderate intensity aerobic exercise on the error monitoring function of METH-dependent individuals through experiment 1,and to explore the effect of acute moderate intensity aerobic exercise on the inhibition control function of METH-dependent individuals and its potential mechanism through experiment 2.Methods: In experiment 1,29 METH-dependent subjects were recruited by using event-related potential(ERP)technique and Stop-signal task paradigm.They were randomly assigned to complete 20-minute moderate intensity(65%-75% HRmax)aerobic exercise and meditation tasks.The objective of this study was to explore the effects of acute moderate intensity aerobic exercise on error monitoring ability of METH-dependent individuals by examining craving,reaction time,accuracy and ERN components.In experiment 2,the inhibition control functions of METH-dependent individuals were explored by using Encephalofluctuation technology(ET).25 METH-dependent individuals were recruited to perform 20 minutes of moderate intensity aerobic exercise and meditation tasks at random by using cross-over design.In addition to dopamine,serotonin and glutamate,the other behavioral indicators remained unchanged.Results: In experiment 1,after aerobic exercise,craving of METH-dependent individuals decreased significantly.ERN components of METH-dependent individuals were activated significantly in prefrontal cortex under control tasks.We believed that after aerobic exercise,the error monitoring function of METH-dependent individuals showed stability,which may be related to the changes of neurotransmitters induced by exercise.Therefore,experiment 2 was used to explore and results found that after aerobic exercise,the craving of METH-dependent individuals repeated the results of experiment 1.At the same time,METH-dependent individuals showed higher accuracy rate and quickest stop-signal reaction time under aerobic exercise task,but no significant results were found in the control task,indicating that aerobic exercise enhanced their inhibition control function.It increased the release of dopamine related to the inhibition control function,but had no significant effect on neurotransmitters such as glutamate and serotonin.Conclusion: Moderate intensity aerobic exercise could bring the best rehabilitation benefit to the group of METH-dependent individuals,and inhibition control function may be the key link of rehabilitation treatment for drug dependence.The results of this study provided a reference clue for drug dependence rehabilitation therapy,and had a certain guiding role in rehabilitation practice.